Year: 2022

CALCULATIONS. “The realistic prediction of antihelium flux accessible to AMS02 experiment is now under way involving analysis of possible sources of energetic antinuclei from antimatter globular cluster and their propagation in galactic magnetic fields.” https://www.mdpi.com/2218-1997/7/9/347/htm View in LinkedIn

BOUNDARIES. “It should be noted that formation of antimatter domains can be accompanied by domain walls, which either disappear, as it takes place in, or collapse in black holes, leaving gravitational wave background or primordial black holes, which deserve special study in the context of multimessenger probes of the considered scenarios.” https://www.mdpi.com/2218-1997/7/9/347/htm View in LinkedIn

THE OTHER EXISTENTIAL THREAT. “After launching in November, NASA will test its asteroid deflection technology in September 2022 to see how it impacts the motion of a near-Earth asteroid in space.” (Keep calm and carry on). https://lnkd.in/dew7Qkc9 View in LinkedIn

Keep calm and carry on. Llafranc an the costa brava. Drinks by the Mediterranean while we quietly ignore the various existential threats facing the planet. View in LinkedIn

FRAGMENT FROM NATURE for this weekend focuses on an article titled ‘Inflammaging: a new immune–metabolic viewpoint for age-related diseases.’ For some decades there has been the growing impression that the common pathway of many chronic diseases is inflammation. This article skillfully summarizes the evidence, https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

THE TWO BIG ONES. “The most challenging events for an organism’s survival are nutrient deprivation and infection by pathogens; therefore, competition for food and the response to infectious diseases are the main factors that determine the ecological dynamics of populations and species and influence evolution.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

CO-EVOLUTION. “Accordingly, food sources, metabolism, endocrine responses, innate immune responses and inflammation co-evolved, and the macrophage is a master cell at the interface between metabolism and immunity. Several lines of evidence suggest that the immune, metabolic and endocrine responses co-evolved.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

AGEING AND INFLAMMATION. “Ageing and age-related diseases share some basic mechanistic pillars that largely converge on inflammation. During ageing, chronic, sterile, low-grade inflammation — called inflammaging — develops, which contributes to the pathogenesis of age-related diseases. “ https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

DEGRADING SYSTEMS. “From an evolutionary perspective, a variety of stimuli sustain inflammaging, including pathogens (non-self), endogenous cell debris and misplaced molecules (self) and nutrients and gut microbiota (quasi-self).” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

DEGRADATION RECEPTORS. “A limited number of receptors, whose degeneracy allows them to recognize many signals and to activate the innate immune responses, sense these stimuli. In this situation, metaflammation (the metabolic inflammation accompanying metabolic diseases) is thought to be the form of chronic inflammation that is driven by nutrient excess or overnutrition; metaflammation is characterized by the same mechanisms underpinning inflammaging.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn