Year: 2022

DYSBALANCE. “It is tempting to speculate that altered metabolism could provide feedback to cellular growth and clock function, contributing to the unbalanced state characteristic of tumor cells.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

VALIDATION. “These findings in cells cultured in vitro have been further validated in vivo via genetically engineered mice.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

“CLOCK, BMAL1, and MYC are all transcription factors that share a highly similar basic helix-loop-helix (bHLH) protein domain, allowing these proteins to recognize the same promoter element, the enhancer box (E-box) sequence, in the regulatory regions of target genes.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

GENE REWIRING. “It is thus tempting to speculate that a rewiring could take place during tumorigenesis, whereby the balance of clock-controlled transcription can be lost and consequently compensated for by oncogenic MYC signaling.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

SO ENDS this first of two weekends on an article about the relationship of the cellular circadian clock to cancer formation from the epidemiological and genetic evidence. Strange work hours have long been considered unhealthy, but this review compellingly suggests that it is actually carcinogenic. It is curious that it involves the circadian clock, and that it is so delicately balanced between health and disease. View in LinkedIn

MIND-WANDERING. “Until the mid-1990s, cognitive psychology and the emerging field of cognitive neuroscience were dominated by a task-centric view of mental processes. Experimental designs were carefully constructed to minimize the effects of task-unrelated thoughts that were generally viewed as experimental 'noise'.” (Excellent article). https://lnkd.in/eFtRGz4j View in LinkedIn

This remarkable self-taught mathematical artist achieved such expertise that he was corresponding with leading mathematicians like Roger Penrose and Coxeter. View in LinkedIn

“REALITY is a tiny fraction of the true "hyper-reality" which we picture as a Hilbert space.” https://lnkd.in/gDaxUYAS View in LinkedIn

ORIGINS. “As part of this initial R-process which produced the Big Bang, the simplest assumption is that our universes have an R-process which proceeds indefinitely, to produce a single reality, which foliated spacetime in a double plane of simultaneity across the whole of the tiny universes at plus and minus the Planck time.” https://lnkd.in/gDaxUYAS View in LinkedIn

THE QUESTION. “Why were the two U-processes each dominated by superpositions moving outward from the Big Bang along the time dimension? Perhaps because at the Planck time, or any very early time, superpositions evolving backward in time would have very little potential duration, compared to many very long potential durations away from the origin.” https://lnkd.in/gDaxUYAS View in LinkedIn