Year: 2022

L-FORMS AND VITAMIN D DYSREGULATION. "Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency. Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes." https://lnkd.in/eRQEiar View in LinkedIn

"VITAMIN D DEFICIENCY is a critical factor in the pathology of at least 17 varieties of cancer, as well as autoimmune diseases, diabetes, osteoarthritis, periodontal disease, and more. Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of vitamin D3, the active form of vitamin D." https://lnkd.in/eD6Q7PW View in LinkedIn

VITAMIN D RECEPTOR (VDR). "Activation of VDR signaling affects many processes, including calcium metabolism, apoptosis, immunity, and autophagy." https://lnkd.in/eD6Q7PW View in LinkedIn

VDR ACTIVATION AFFECTS AUTOPHAGY. "Autophagy influences various aspects of disease progression, including stress adaptation, lifespan extension, development, immunity, and cancer." https://lnkd.in/eD6Q7PW View in LinkedIn

AUTOPHAGY AND VDR. "The functions of autophagy include tumor suppression, antimicrobial defense, inhibition of cardiac hypertrophy, anti-aging, and others. Remarkably, the functions of autophagy overlap with those of the vitamin D/VDR signaling." https://lnkd.in/eD6Q7PW View in LinkedIn

BACTERIA AND VDR. "Vitamin D receptor (VDR) plays an essential role in gastrointestinal inflammation. Most investigations have focused on the immune response; however, how bacteria regulate VDR and how VDR modulates the nuclear factor (NF)-κB pathway in intestinal epithelial cells remain unexplored." https://lnkd.in/eRmcyfQ View in LinkedIn

VDR AND DISEASE. "Scientists have associated vitamin D and the receptor with many types of cancer, as well as osteoporosis, heart disease, diabetes, inflammatory bowel disease, and infection." https://lnkd.in/eavdUZn View in LinkedIn

"VITAMIN D DEFICIENCY is a known factor in the pathology of inflammatory bowel disease and colon cancer ... but there have been very few reports about how bacteria might play a role by targeting the vitamin D receptor. Our work suggests one possible mechanism, by working through the vitamin D receptor, a sensor and regulator for the majority of functions of vitamin D.” https://lnkd.in/eavdUZn View in LinkedIn

SALMONELLA AND VDR. "Salmonella is able to regulate the vitamin D receptor, increasing its activity and determining where in the colon the receptor is active. vitamin D receptor plays a key role in defending the body from assault by Salmonella and squelching inflammation. The receptor stops a molecule known as NF-Kappa B, a well-known master player in the world of inflammation, by binding to it and preventing it from activating other inflammatory molecules." https://lnkd.in/eavdUZn View in LinkedIn

BACTERIA AND VDR. "VDR expression and distribution were specifically regulated by the bacteria-induced inflammation. We found that pathogenic bacteria increased VDR expression, whereas commensal bacteria did not change VDR expression in colon epithelial cells." http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/320.10 View in LinkedIn