Year: 2022

MANY AVENUES. "Given the existence of many DNA polymerases whose fidelity can vary over a 10,000-fold range, and given the multiple and complex transactions that all require DNA synthesis to maintain genome stability, there are probably many more ways to generate mutant cells that thrive despite reduced DNA synthesis fidelity. Thus, the current list of associations between defective DNA synthesis fidelity and cancer is almost certainly incomplete." http://www.sciencedirect.com/science/article/pii/S1535610803000278 View in LinkedIn

MUTATIONS AND CANCER. "Many point mutations that occur in cancer cells arise from the error-generating activities of DNA polymerases. However, the ability of some of these enzymes to bypass DNA damage may actually defend against chromosome instability in cells and at least one DNA polymerase, POLζ, is a suppressor of spontaneous tumorigenesis." https://lnkd.in/e_FVkkp View in LinkedIn

RX TARGETS. "Because DNA polymerases can help cancer cells tolerate DNA damage, some of these enzymes may be viable targets for therapeutic strategies." https://lnkd.in/e_FVkkp View in LinkedIn

GENOME EDITING. "Phylogenetic analyses as well as GenBank database comparisons show that most natural genome-editing competences are not of cellular origin but represent original skills of viruses." https://lnkd.in/e-pJFM6 View in LinkedIn

PROOFREADING AND MUTATION. "DNA viruses retain their proofreading function and have a lower mutation rate than RNA viruses, even though they share a generally similar lifestyle." https://lnkd.in/e9KGgbm View in LinkedIn

TRADE-OFF. "The majority of the new viral mutations are deleterious to the virus from a natural selection perspective. Was the high mutation rate of viruses a trade off for selection for faster replication rates?" Faster replication rates afforded the ability to evolve more rapidly and adapt to new niches faster. https://lnkd.in/e9KGgbm View in LinkedIn

RANDOM MUTATIONS, or more recently, horizontal gene transfer, have been widely considered to be the primary driver of genetic diversity, and with that diversity, a richer toolbox for selective evolutionary pressures to squeeze out newly adapted genomes and creatures from the edges of their Bell Curves. View in LinkedIn

PRECISE EDITING. "It is becoming increasingly evident that the driving forces of evolutionary novelty are not randomly derived chance mutations of the genetic text, but a precise genome editing by omnipresent viral agents." An extraordinary statement to wrap your mind around, and contrary to previous thinking. Re-read and re-digest. https://lnkd.in/e-pJFM6 View in LinkedIn

VIRAL GENOME EDITING AS EVOLUTIONARY DRIVERS. "These competences integrate the whole toolbox of natural genetic engineering, replication, transcription, translation, genomic imprinting, genomic creativity, enzymatic inventions and all types of genetic repair patterns." https://lnkd.in/e-pJFM6 View in LinkedIn

GENOME EDITING IS IMPORTANT. "There is growing evidence that natural genome-editing competences of viruses are essential for the evolution of the eukaryotic nucleus, the adaptive immune system and the placental mammals." https://lnkd.in/e-pJFM6 View in LinkedIn