MUTANT SWARM. “According to the “cloud” hypothesis, pools of infectious isoform of prion protein (PrPSc) within individual strains or isolates are intrinsically heterogeneous; the heterogeneity presumably arises due to spontaneous variation in PrPSc structure. Upon changes in the replication environment, minor variants that fit best to replicate in the new environment receive selective advantages.”
https://lnkd.in/dd6Nm4B