THE UNDERDETERMINATION PROBLEM. “This inference is complicated by the high variable to observation ratio of genomics, which causes the intrinsic and heavily underdetermined nature of the genomics/systems biology marriage. Experimental designs involving time courses and or perturbation can provide significantly more, but rarely enough, information on the underlying system structure. Computational biologists address this high underdetermination problem using strategies such as variable selection.”
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022