TARGETED HYPERMUTATION. Genome reorganization does occur in response to stress by targeted stochastic mutation as in the case of targeted somatic hypermutation in immune cells, where the hypervariable gene region only on immunoglobulin, which mutates hugely (100,000 to 1,000,000 fold change) in response to stress. Imports directionality while using stochasticity.
https://lnkd.in/eBKWC7d