COMPLEX CO-EVOLUTION. “As they co-evolved with their host cells, the original endosymbionts lost most of their genetic repertoires, either definitively or through transfer to the host’s nuclear genome. In parallel, having picked up suitable signal sequences, the products of many nuclear genes of endosymbiotic origin were re-routed back to their original compartment, together with new nucleus-encoded proteins, via intracellular trafficking routes.”
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