“PRION DISEASES are devastating neurological disorders caused by the propagation of particles containing an alternative β−sheet-rich form of the prion protein (PrP). Genes paralogous to PrP, called Doppel and Shadoo, have been identified, that also have neuropathological relevance. PrP is highly conserved across mammals, typically with > 50% sequence identity relative to human.”
https://lnkd.in/e8tmC2k