SMART INSULIN. “We prepared a derivative of insulin with a molecular switch to provide glucose-mediated activation of the insulin molecule, toward the generation of more autonomous therapy with improved blood glucose control. This modified insulin, when administered in a diabetic mouse model, restores blood glucose levels following a glucose challenge (i.e., a simulated meal) faster than both standard insulin and a clinically used long-lasting insulin derivative.”
http://www.pnas.org/content/112/8/2401.abstract
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022