BIOLOGIC DRUGS WILL GENERATE 160 BN USD IN WORLDWIDE SALES IN 2013, and be 50% of new drug approvals in the US in coming years. Most are monoclonal antibodies. Caesar Milstein of the Cambridge University MRC Unit invented monoclonals. A framed letter on his office wall was the irritated response to his request to the MRC for a patent. It suggested that Dr. Milstein stop pestering them with these foolish requests. Needless to say, this was an historic blunder by this beleaguered licensing officer.