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CONSERVED REGULATOR. "Given that the Paf1 complex is conserved across kingdoms and because animals also alter their body plan in response to repeated mechanical stresses, these findings also raise the possibility of a common mechanism for recording multiple mechanical deformations and translating them into developmental changes." https://lnkd.in/dv9swtZ View in LinkedIn

CRITICAL THRESHOLD. "Understanding the mechanisms underlying the morphological divergence of species is one of the central goals of evolutionary biology. How many genes contribute to species divergence?" https://lnkd.in/dGSGXuT View in LinkedIn

BROAD EFFECTS OF REGULATORS. "These lines of evidence link VIP3 to stem thigmomorphogenesis. We also present evidence that other components of the Paf1 complex are required for thigmomorphic responses in both the stem and the root." https://lnkd.in/dv9swtZ View in LinkedIn

GENOTYPE ASSUMPTION. "One of the great challenges in molecular and evolutionary biology is to explain the link between giant evolutionary leaps, such as the colonization of land by plants or the emergence of vertebrates, and the underlying genetic and genomic changes. For a long time, biologists thought that such profound changes in phenotype would be accompanied—if not driven by—equally dramatic upheavals at the genetic level." https://lnkd.in/eNHFjJ8 View in LinkedIn

REGULATOR EVIDENCE. "We present four lines of evidence to support the conclusion that a lesion in VIP3 is responsible for the thigmomorphic defects seen in ths1 mutants." https://lnkd.in/dv9swtZ View in LinkedIn

REGULATION VS NOVELTY. "The great leap forward. Major evolutionary jumps might be caused by changes in gene regulation rather than the emergence of new genes." https://lnkd.in/eNHFjJ8 View in LinkedIn

OTHER REGULATORS. "We also show that THS1/VIP3 is required for both global and genic levels of H3K36 methylation and for upregulation of two canonical touch-inducible loci in response to touch stimulation." https://lnkd.in/dv9swtZ View in LinkedIn

NEW GENES. How do they arise? Are there gene life cycles in evolutionary terms? What permits some to persist? And, how do genes die and become extinct? How is all this regulated within the genome? View in LinkedIn

GENE EVOLUTION. We have completed a small peek into synthetic DNA and the creation of synthetic life. Now our journey starts to look at gene evolution itself, the heart of the engine of life. View in LinkedIn

FRACTIONAL MUTATIONS. "Because only a tiny fraction of all mutations that have ever occurred during evolution have been fixed, the “successes” that we see today provide an incomplete or even biased understanding of the evolutionary process." The evolutionary rubbish bin is essentially hidden and likely very full. http://science.sciencemag.org/content/352/6287/769 View in LinkedIn