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BIG DATA IN EPIGENOMICS: "Generation of enormous amounts of data has driven the need for more advanced storage solutions and shared access through a range of public repositories. The number of such biomedical resources is increasing constantly and mining these large and diverse data sets continues to present real challenges."" " http://lnkd.in/csWFKP. View in LinkedIn

WE KNOW LITTLE. "We have been astonished by how little there is known about massive regions of the tree of life. This is the first systematic effort to address this enormous knowledge gap. One of the most significant contributions is that based on these data, we provided names for many of these lineages which, like most star systems, were just numbered previously...Yet this is just a start. We are talking about probably millions of microbial species that remain to be described"" " http://www.eurekalert.org/pub_releases/2013-07/dgi-bib071013.php View in LinkedIn

LARGE CANCER STUDIES: "Epigenetic abnormalities have been found to be causative factors of cancer, genetic disorders and pediatric syndromes, as well as ...autoimmune diseases and aging.Two of the large-scale project initiatives for cancer research include ICGC and TCGA (The Cancer Genome Atlas). TCGA...intends to chart the genomic changes involved in more than 20 types of cancers."" " http://lnkd.in/csWFKP. View in LinkedIn

GREAT UNKNOWN HERE ON EARTH. "Cosmologists have only mapped half of one percent of the observable universe and the path ahead in environmental genomics is similarly daunting. "There is still a staggering amount of diversity to explore, To try to capture 50 percent of just the currently known phylogenetic diversity, we would have to sequence 20,000 more genomes, and these would have to be selected based on being members of underrepresented branches on the tree. And, to be sure, these are only what are known to exist."" " http://lnkd.in/WfwgFA. View in LinkedIn

DATA WAREHOUSING is needed for giant biological data mining projects in epigenetics: "Recently-launched large-scale initiatives include, among others, IHEC (International Human Epigenome Consortium), which plans to map up to 1,000 reference epigenomes within a decade, and the Human Epigenome Project (HEP), which aims to identify, catalog and interpret genome-wide DNA methylation patterns of all human genes in all major tissues."" " http://lnkd.in/csWFKP View in LinkedIn

CENSUS OF MATTER in the universe by the European Space Agency's Planck Spacecraft (2012). " "" "Planck's New Recipe of the Universe: More Matter, Less Dark Energy - D-brief | DiscoverMagazine.com http://lnkd.in/WppDHc View in LinkedIn

EPIGENETICS and cancer diagnosis: a good Q&A. " " http://lnkd.in/VVmCxT View in LinkedIn

WE HAVE THEORIES for our known universe that make us quite smug, until we remember that these theories only describe 5% of the total mass and energy in our universe. " " http://onswipe.com/thedailygalaxy/ View in LinkedIn

POST-GENOMIC ERA of epigenetics will mean that purely sequence data for some disease genes may not be enough. Assessment of whether a gene is active or not (by methylation analysis etc) is an important emerging consideration. New sample prep methods may be needed to assess both sequences and epigenetic changes. See this great slide show. " " http://lnkd.in/rUwHBY View in LinkedIn

NEW DRUGGABLE HORIZONS are opening up? If the currently addressed percent of the druggable human genome was estimated at some 2-5%, it is probable that this percentage will drop dramatically as we learn what functions the non-coding sequences ("Junk DNA") serve in the human genome (since they occupy the vast majority of the human genome). They will now be numerous novel druggable targets (with new Mechanisms of Action) as they get revealed. This is great news for pharmaceutical ventures. View in LinkedIn