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DNA CONTENT. "However, the genome size of many eukaryotes does not appear to be related to genetic complexity. For example, the genomes of salamanders and lilies contain more than ten times the amount of DNA that is in the human genome, yet these organisms are clearly not ten times more complex than humans." https://lnkd.in/d3J4fHw View in LinkedIn

LARGER GENOMES AND MORE COMPLEXITY. "The genomes of most eukaryotes are larger and more complex than those of prokaryotes. This larger size of eukaryotic genomes is not inherently surprising, since one would expect to find more genes in organisms that are more complex." But do not underestimate the sophistication of gene streamlining through outsourcing, as in bacteria and viruses. https://lnkd.in/d3J4fHw View in LinkedIn

Ref for previous uncited quote: Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation" "Munshi A, Mohan V and Ahuja YR View in LinkedIn

JUNK RELATED TO COMPLEXITY. "A comparative analysis has shown that the complexity of organisms is inversely proportional to the protein coding genes in their genomes. In fact, the ncRNA-mediated gene regulation is widespread among higher eukaryotes, when compared to prokaryotes. In humans, about 98 percent of the total transcriptional output is non-coding." (ncRNA = non coding or junk RNA). View in LinkedIn

JUNK RELATED TO COMPLEXITY. "A comparative analysis has shown that the complexity of organisms is inversely proportional to the protein coding genes in their genomes. In fact, the ncRNA-mediated gene regulation is widespread among higher eukaryotes, when compared to prokaryotes. In humans, about 98 percent of the total transcriptional output is non-coding." (ncRNA = non coding or junk RNA). " "Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation" "Munshi A, Mohan V and Ahuja YR View in LinkedIn

CONSERVATION SIGNIFICANCE. "Highly conserved DNA sequences are thought to have functional value. The role for many of these highly conserved non-coding DNA sequences is not understood. Ultra-conserved elements or sequences (UCEs or UCRs, ultra-conserved regions) that share 100% identity among human, mouse and rat were first described by Bejerano and colleagues in 2004." https://lnkd.in/eZmb7gi View in LinkedIn

NEW VIEW. "The conclusion was that a vast majority of the genome was transcribed." https://lnkd.in/dCi-e6y View in LinkedIn

CENTRAL DOGMA RECALIBRATED. "Recent studies "challenge this conclusion, suggesting that transcriptional control makes the larger contribution." http://science.sciencemag.org/content/347/6226/1066 View in LinkedIn

MISTAKEN FOR NOISE. "Yet the significance of this finding was not recognized for at least five years since the “DNA like RNA” was less than 1% of total RNA (mostly rRNA) and thus assumed to be irrelevant noise." https://lnkd.in/dCi-e6y View in LinkedIn

DOGMA. "If the rates for one of these steps differ much more than the rates of the other three, that step would be dominant in defining the variation in protein expression. Over the past decade, system-wide studies have claimed that in animals, differences in translation rates predominate." http://science.sciencemag.org/content/347/6226/1066 View in LinkedIn