linkedin post 2018-04-05 04:09:31

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NECESSARY TENSION. “Jacob is one of the fathers of modern Biology, and in his monumental work The Logic of Life he recounts the polarity that has always existed in biological science between analytical and synthetic traditions, between reductionism and holism.” https://lnkd.in/drJfrU7 View in LinkedIn
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linkedin post 2018-04-05 04:08:11

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SWINGS AND PENDULUMS. “While system-centric studies in specific subfields of biology can be traced back to the 1950s and 1960s, it was not until the mid-1990s that systems biology developed into a major counter-movement that would grow to challenge the reductionist approach.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn
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linkedin post 2018-04-05 04:05:45

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PUTTING HUMPTY BACK TOGETHER AGAIN. “Neuroscience, physiology, and ecology all converged independently on the idea that it was as important to study and model the system of parts and their interactions as to fully analyze the individual parts alone.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn
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linkedin post 2018-04-05 04:05:17

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FAILINGS OF REDUCTIONISM. “Several subfields of biology have discovered independently that detailed studies of the structure and function of individual parts in detail did not give them a good understanding of the emergent properties of the interactions of many parts within a whole system.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn
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linkedin post 2018-04-05 04:04:35

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COMMON THREADS. “Running counter to this natural balkanization are the handful of organizing principles that span across all of biology such as natural selection and the central dogma of molecular biology. Why would anyone look for an alternative to reductionist biology after one hundred fifty years of unrelenting success?” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn
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linkedin post 2018-04-06 04:07:23

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VOILA! “All forms of functional genomics, epigenomics, proteomics, etc. approaches should work in your organism of choice, as long as you can collect/breed/obtain specimens in sufficient numbers. Single cell sequencing techniques only require good dissociation, transcriptome library preparation and sequencing protocols and, voila, a first glimpse into cellular diversity and the evolution of cell types is within reach.” http://extavourlab.com/pdfs/papers/2016_Extavour_CurrOpGenetDev.pdf View in LinkedIn
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