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NEW DISCIPLINE. “A science of complex matter, of informed, self-organized, evolutive matter.” https://lnkd.in/dN969hA View in LinkedIn

UNSTABLE DIVERSITY. “When the assembly occurs only in a narrow range of conditions, the system is unstable and presents a singularity; it may also display a bifurcation or a switching point between different assemblies. On the other hand, sensitivity to perturbations, while limiting the operation range, introduces diversity and adaptability in the self-organization process.” https://lnkd.in/dN969hA View in LinkedIn

CHEMICAL EMERGENCE. “At each level of increasing complexity novel features emerge that do not exist at lower levels, which are deducible from but not reducible to those of lower levels.” https://lnkd.in/dN969hA View in LinkedIn

ADAPTIVE MATTER. “In the long-range perspective, the development of chemical science is toward complex systems, spanning the broadest outlook from divided to condensed matter then to organized and adaptive matter, on to living matter and thinking matter, up the ladder of complexity.” https://lnkd.in/dN969hA View in LinkedIn

EVOLUTIVE CHEMISTRY. “The combination of the features of supramolecular systems—information and programmability, dynamics and reversibility, constitution and diversity—leads toward the emergence of adaptive/evolutive chemistry. It is, by essence, of supramolecular nature because it is determined by interaction with an external entity. It may be constitutional and/or morphological (as occurs in “induced fit” for instance). Adaptive chemistry implies selection and growth under time reversibility.” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY SELECTION requires dynamic diversity (constitutional and/or morphological) on which to operate. This is made possible by the implementation of CDC responding to the pressure of either internal or external factors. Selection has an implicit information content. It is also truly a supramolecular process, because it occurs in relation to interactions with surroundings (which may be either the medium or a more or less distant part of a folded macromolecule).” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY DESIGN has been pursued with the goal to achieve full control over the output supramolecular entity by means of correctly instructed components, specific interaction algorithms, and (as much as possible) strict programming. Design is knowledge-based and has an explicit information content.” https://lnkd.in/dN969hA View in LinkedIn

MOLECULAR EVOLUTION. “Whereas preorganization relies entirely on design, supramolecular self-organization introduces in addition the possibility to let the system build up by selection.” https://lnkd.in/dN969hA View in LinkedIn

MOLECULAR COMPUTATION. “The combination of different recognition/instruction features in a molecular program opens a door to the design of self-organizing systems capable of performing molecular computation. Computing by self-assembly may yield a powerful alternative to conventional models. Recent studies described the use of biomolecules and DNA-based protocols to solve computational problems.” https://lnkd.in/dN969hA View in LinkedIn

OUTPUT IMPLICATIONS. “The processing of the same ligand information by different interaction algorithms (e.g., through the use of different sets of metal ions or of different H-bonding effectors) allows the controlled self-organization of different output architectures, resulting in multiple expression of molecular information, through postinformational (postgenomic!) operations. Such a one code/several outputs scheme, in addition to the one code/one output (product) mode, also has in principle significant implications in biology.” https://lnkd.in/dtRiQxQ View in LinkedIn