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PRESERVING GENOME FIDELITY. "Companion cell DNA does not contribute to the zygotic genome, and therefore reactivation of companion cell transposable elements does not risk the genome fidelity of the next generation. Together with its vital biological function to facilitate fertilization and promote postfertilization development with reduced dependence on water, the ability of the gametophyte to protect the integrity of the zygotic genome has probably contributed to the maintenance of this distinct “generation” during angiosperm evolution." http://www.sciencedirect.com/science/article/pii/S1534580713000427 View in LinkedIn

BY PRECEDENT. “Because biological processes are often executed by protein complexes and fine-tuned by regulatory factors, the first-order protein-protein interactors of known longevity genes are likely to participate in the regulation of longevity.” https://lnkd.in/dzD-3br View in LinkedIn

SILENCING WORK. "Once cell fates are specified within the gametophytes, the current data suggest that “information flow” reverses with the companion cells of the pollen and embryo sac acting to silence transposable elements in the germ cells. Presumably, this would act to reinforce the default systems that repress transposable element activity in somatic cells, perhaps because of an increased requirement for genome integrity in the gametes caused by the gametic chromatin being differently packed from that of somatic cells." http://www.sciencedirect.com/science/article/pii/S1534580713000427 View in LinkedIn

MITONUCLEAR PROTEIN GENES. "Collectively these data demonstrate that MRPs represent an evolutionarily conserved protein family that ties the mitochondrial ribosome and mitonuclear protein imbalance to the mitochondrial unfolded protein response, an overarching longevity pathway across many species.” http://www.nature.com/nature/journal/v497/n7450/abs/nature12188.html View in LinkedIn

EGG DOMINATED FATES. "Fate specification within the reduced gametophytes of flowering plants is also dependent on intercellular signaling. In embryo sacs, the egg, once specified via a hormone gradient, assumes a dominant role and generates signals that determine the fates of its neighbors." http://www.sciencedirect.com/science/article/pii/S1534580713000427 View in LinkedIn

LIFE SPAN AND STRESS. “Known longevity genes are enriched for roles in stress tolerance and development. Many mutations that modulate longevity were identified by virtue of their contribution to stress response pathways or by homology to genes of this kind.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

LIFE SPAN REGULATORS. “Our results suggest that the worm and human longevity networks are functionally relevant and possess a high predictive power for identifying new longevity regulators.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

GENES AND LIFE SPAN. “Curran and Ruvkun explored this overlooked gene set by inactivating essential genes postdevelopmentally, revealing 64 genes required for development that extend lifespan when inactivated during adulthood. Nevertheless, many important longevity genes likely remain unidentified.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048282 View in LinkedIn

DARWINIAN LIFE SPAN. “We interpret life span as an inherent property of self-organizing systems that, accordingly, maintain species-specific limits for the entire complex of fitness traits. We conclude that Darwinian approaches provide unique opportunities to discover the biological bases of longevity as well as devise individual specific medical or other interventions toward improving health span.” http://link.springer.com/chapter/10.1007/978-1-4939-2404-2_1 View in LinkedIn

COMPOSITE TRAIT. “As an important life-history trait, longevity shows ontogenetic relationships with other complex traits, and hence may be viewed as a composite trait. Factors that influence the origin and maintenance of diversity of life are ultimately governed by Darwinian processes.” http://link.springer.com/chapter/10.1007/978-1-4939-2404-2_1 View in LinkedIn