linkedin post 2018-09-13 04:06:10

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FITNESS EFFECTS. "Anatagonistic Pleiotropy (AP) hypothesis and the mutation accumulation hypotheses. These hypotheses are distinguished by the early effects of genes and mutations. AP refers to traits with early positive effects that trade for or against later negative effects while mutation accumulation refers specifically to costly mutations with no fitness effect early in life." View in LinkedIn
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linkedin post 2018-09-13 04:01:50

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LEAN TIME EXTENSION. "The IGF-1 signaling pathway is involved in regulating life span in several model organisms, including...nematodes, and rodents. Several loci interact in what the authors term a “survival pathway”. The authors suggest that this pathway is activated to “survive unfavorable conditions in an effort to reproduce at a later time” View in LinkedIn
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linkedin post 2018-09-13 03:59:11

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GENETIC DEATH. "In several model organisms, the specific genes influencing life span have been identified and there are now numerous examples where a molecular network promotes fitness early in life only to result in senescence and decreased fitness later. These are the genetic mechanisms for the Anatagonistic Pleiotropy (AP) hypothesis." View in LinkedIn
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linkedin post 2018-09-16 04:45:48

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CELL SPECIFICITY WITH SINGLE CODE. “Which proteins and RNAs are made when and where is not fully specified. This is why it is possible for the 200 or so different cell types in an organism such as the human to make those cell types using exactly the same genome. A heart cell is made using precisely the same genome in its nucleus as a bone cell, a liver cell, pancreatic cell, etc.” http://rsfs.royalsocietypublishing.org/content/2/1/55 View in LinkedIn
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linkedin post 2018-09-16 04:43:09

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READ-ONLY VERSUS READ-WRITE. “But the genome is not a fixed program in the sense in which such a computer program was defined when Jacob and Monod introduced their idea of ‘le programme génétique’. It is rather a ‘read–write’ memory that can be organized in response to cellular and environmental signals.” http://rsfs.royalsocietypublishing.org/content/2/1/55 View in LinkedIn
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linkedin post 2018-09-16 04:39:20

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APPARENT GENE PRIMACY. “The sequences of DNA triplets form templates for the production of different amino acid sequences in proteins. Amino acid sequences do not form templates for the production of DNA sequences. That, in essence, is what was shown. The template works in only one direction, which makes the gene appear primary.” http://rsfs.royalsocietypublishing.org/content/2/1/55 View in LinkedIn
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