Category: Uncategorized

KILLING GENOMES. "Genetically regulated programmed cell death is a phenotype that is characterized by the rapid disappearance of the cell that is expressing it. In other words, genes that encode effectors of programmed cell death can be viewed as allowing a phenotype that is the grave of the genome that expresses them." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

GRAVE OR CRADLE. "Simply put, the phenotype represents either the grave of a given genome or its vehicle into the next generation." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

DEATH OF WEAK PHENOTYPES. "Natural selection sanctioned by death is a process of competition between phenotypes whereby genomes allowing for poorly adapted phenotypes do not get transmitted into the next generation, while genomes that allow fitter phenotypes become selected." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

MUTATION AND PHENOTYPE. "Genetic mutation leads to genetic diversification, and hence to phenotypic diversity." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

PHENOTYPE TARGET OF SELECTION. "Natural selection does not act directly on genes, but on the phenotypes they allow the cell that encodes them to achieve." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

SELFISH TO ALTRUISTIC. "It is interesting to think that the genetic modules that are now involved in the regulation of what we call 'altruistic' regulated programmed cell death may have initially emerged and become selected as 'selfish genetic modules', for the sole reason that encoding an executioner and an inhibitor of the executioner just made them good at propagating themselves." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

WOLBACHIA RIDDLED WITH PHAGE WO. "Nearly all sequenced Wolbachia genomes, with the exception of those acting as obligate mutualists, harbour prophage WO." https://lnkd.in/dG3vir9 View in LinkedIn

ADVANTAGE OF DEATH. "Through a radical change in perspective, we have now seen that the emergence of programmed cell death can be envisioned as resulting from a selective spreading advantage conferred by genetic modules regulating cell death and survival to the genomes able to express them." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

WOLBACHIA HOST WITHIN A HOST. "For instance, phage WO infects the obligate intracellular alpha-proteobacteria Wolbachia, which in turn infect an estimated 40% of the most speciose group of animals worldwide—arthropods (as well as filarial nematodes." (Phage WO is the name of a type of bacteriophage). https://lnkd.in/dG3vir9 View in LinkedIn

SINGLE CELLED ORIGINS. "Programmed cell death is an ancient and conserved feature in most, if not all, single-celled eukaryote organisms, and that programmed cell death emerged at the time - or prior to the time - of the emergence of the first eukaryotes." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn