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PLANT Cell Death. "In plants, cell death is part of the normal cycle of the organism. Developmental cell death is observed in many plant tissues, being crucial for instance for senescence of leaves and flowers, formation of pollen and seeds and terminal differentiation of vascular elements. Moreover, plant cells undergo Programmed Cell Death in response to infection." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

"CELL DEATH regulated by a genetic program, or Programmed Cell Death (PCD), is a fundamental mechanism of homeostasis of tissues." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

SKIN DEATH. "A process involving programmed cell death which we are all familiar with is death of skin cells. The skin is constantly being renewed and this renovation involves death of cells in outer layers of the skin. These cells do not die by apoptosis, but by a process called ‘cornication’ or ‘keratinization’ of the outer layers of the epidermis." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

CELL DEATH BY MURDER. "Cytotoxic lymphocytes (CTL) and Natural Killer (NK) cells owe their names to their ability to induce death of their target cells. In order to avoid propagation of a virus, cytotoxic cells attack and kill the infected cells and they use several effector mechanisms in order to do so." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

CASPASES "Apoptotic pathways are fairly similar in nematodes, and vertebrates. Caspases are required for apoptosis in all animals studied and so are their activators (Apaf‐1‐like molecules). In mammals, the mitochondrial pathway is of great relevance, because it is activated in response to multiple stimuli. Mitochondria (and cytochrome c) are required for apoptosome‐mediated caspase activation in response to a diversity of stimuli, including developmental cues, growth factor withdrawal, heat shock, nutrient deprivation, endoplasmic reticulum stress and DNA damage." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

CONSERVATION AND COMPLEXITY. "During the last nine years, homologues of genes involved in the regulation of programmed cell death in Caenorhabditis elegans have been identified in sponge, in Hydra vulgaris, in the fruitfly Drosophila melanogaster, in zebrafish, in mice and in humans. As frequently occurs during evolution, however, this striking conservation in both sequences and functional properties has been associated with a great level of diversification." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

PERMANENT REPRIEVE. "This very frailty, this permanent reprieve and the interdependence they generate between our cells, are one of the bases of our perennity and our plasticity, allowing our bodies to build themselves, to constantly reconstruct, and to adapt to ever changing environments." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

SOCIAL COUPLING. "The coupling of the fate of each cell to the nature of the interactions it can establish with other cells has led to the concept of 'social control' of cell survival and cell death, allowing a stringent regulation of cell numbers, of their geographic localization, and a constant adjustment of the different cell types that constitute our organs and tissues." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

DUAL FUNCTIONS. "Molecular effectors of cell suicide may also perform other functions unrelated to cell death induction and crucial to cell survival. In this review, I will argue that this new level of complexity, implying that there may be no such thing as a 'bona fide' genetic death program in our cells, might be better understood when considered in an evolutionary context." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

LACK OF EVOLUTION. "Interestingly, since the 1950s, no fundamentally new evolutionary theories of aging have been proposed." http://longevity-science.org/Evolution.htm View in LinkedIn