Category: Uncategorized

SELF-MODIFYING CODE. "In computer science, self-modifying code is code that alters its own instructions while it is executing - usually to reduce the instruction path length and improve performance or simply to reduce otherwise repetitively similar code, thus simplifying maintenance. Self modification is an alternative to the method of "flag setting" and conditional program branching, used primarily to reduce the number of times a condition needs to be tested” https://lnkd.in/ddCjHJk View in LinkedIn

SUPERCLUSTER MIXERS. "Preliminary data suggests that one organizational mechanism makes use of transposons to duplicate or move DNA segments (that code for protein domains) into existing biosynthetic genes. This mechanism could move new genes into existing natural product gene clusters or could move an entire gene cluster of one natural product class...close to that of another class, such that the expression of the "supercluster" becomes coupled and gives rise to a hybrid-type natural product." https://lnkd.in/dEpJBda View in LinkedIn

SELF-REPLICATING CODE LOOPS. "He knew that even then that working from many interactions -- from the bottom up -- it was possible to yield the sort of complex interactions that nature pulls off all the time." https://lnkd.in/dJpC_P3 View in LinkedIn

MOBILE GENETIC ELEMENTS. "What of the many natural products that arise through a mixing of biosynthetic pathways? The data are scant but what is available is suggestive of yet a higher state of organization -- a super-cluster brought about through the action of moveable genetic elements, transposons." https://lnkd.in/dEpJBda View in LinkedIn

VAST INCREASE IN SPEED. "Ten years ago, this program would not have succeeded within any reasonable amount of time. Five years ago, this program would likely have taken days to weeks, possibly even longer. Today, the execution took a matter of minutes. Tomorrow, the program might run in milliseconds." https://lnkd.in/ddNuyJD View in LinkedIn

SELF-MODIFYING CODE. "The term is usually only applied to code where the self-modification is intentional, not in situations where code accidentally modifies itself due to an error such as a buffer overflow." https://lnkd.in/dhsfBc5 View in LinkedIn

SO ENDS this peek at the evolution of metabolic pathways, with evidence both for chaotic assembly and elegant modularity. Biochemistry and genetics are the fundamental templates that nature acts upon, and should be immensely revealing about questions of evolutionary design or happenstance, but so typically of nature, the answers are mixed, with evidence on both sides. View in LinkedIn

MODULAR ARCHITECTURE. "In addition to the recurrence of these topological categories among MBPs, we find that some specific structures are used repeatedly, often in a modular fashion. Specifically, many simple MBPs are used hierarchically as a toolkit for the construction of progressively more complex MBPs (data not shown), similar to what has been observed in real metabolic networks." https://lnkd.in/dUHqnYU View in LinkedIn

ISSUE OF SCALE. "It is possible that hallmarks of metabolic optimality in metabolic network wiring may be observable at the level of global (multi-species) metabolic networks more than at the individual species level." https://lnkd.in/dUHqnYU View in LinkedIn

OPTIMIZED PATHWAYS. "Some computational studies have proposed that the topology of specific metabolic pathways may have evolved towards maximal efficiency, minimal number of steps, or that network properties may reflect optimal organization." https://lnkd.in/dUHqnYU View in LinkedIn