Category: Uncategorized

FIRST SYSTEM FOR SYMMETRY BREAKING. "One involves the interplay between Par proteins, Rho GTPases, and the actomyosin cytoskeleton and mediates asymmetric cell divisions that establish the germline.' https://lnkd.in/dAxynvD View in LinkedIn

TWO SYSTEMS. "The nematode worm Caenorhabditis elegans has produced a wellspring of insights into mechanisms that govern cellular symmetry breaking during animal development. Here we focus on two highly conserved systems that underlie many of the key symmetry-breaking events that occur during embryonic and larval development in the worm." https://lnkd.in/dAxynvD View in LinkedIn

EARLIEST ASYMMETRY. "Over the past few decades, the C. elegans embryo has become a premiere system for studying cellular symmetry breaking in a developmental context. During C. elegans development, nearly every division produces daughter cells with different developmental trajectories." https://lnkd.in/dAxynvD View in LinkedIn

THIRD FINDING. "Declining frequencies of spontaneous asymmetry reversal throughout vertebrate evolution suggest that heart development has become more canalized." https://lnkd.in/dAEUFWY View in LinkedIn

SECOND FINDING. "The molecular pathway directing hearts leftward—the nodal cascade—varies considerably among vertebrates (homology of form does not require homology of development) and was possibly co-opted from a preexisting asymmetrical chordate organ system." https://lnkd.in/dAEUFWY View in LinkedIn

DISTINCTION. "In many situations commonly accepted as SelfModifyingCode, the machine code being modified is a different part of the program than that doing the modifying." https://lnkd.in/dknBRJD View in LinkedIn

BYZANTINE REGULATION. "Upstream cue(s) aside, the regulation of POP-1 asymmetry and binary specification in C. elegans seems byzantine. Indeed, nematodes are the only animal phylum with multiple β-catenin genes, and the nematode β-catenins are extremely diverged in amino acid sequence; most animal genomes encode a single β-catenin, although vertebrates encode one additional β-catenin homolog called plakoglobin." https://lnkd.in/dAxynvD View in LinkedIn

PSEUDO SELF-MODIFYING. "For machine-code, SelfModifyingCode would be machine-code running on the CPU that reaches into its own in-memory or on-disk representation and tweaks that representation. And, even in the case of FPGAs and transmeta toolsets where you have a CPU that is modifiable, it generally isn't self modifying." https://lnkd.in/dknBRJD View in LinkedIn

REWIRING GENE REGULATION. "Our results suggest that promoter gain and loss is an important process in the evolutionary rewiring of gene regulation and may be a significant source of phenotypic diversification." https://lnkd.in/d6USApZ View in LinkedIn

"PROMOTOR TURNOVER has occurred at the majority (>56%) of protein-coding genes since humans and mice diverged. Tissue-restricted promoters are the most evolutionarily volatile where retrotransposition is an important, but not the sole source of innovation." https://lnkd.in/d6USApZ View in LinkedIn