linkedin post 2019-07-07 08:41:44

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SELECTION OF THE PERFECT. "On the other hand, very many enzymes appear not to be involved in metabolic control...and for these we can ask to what extent the selective pressures of evolution have produced the perfect catalyst....In this Account we shall suggest one measure of perfection." http://pubs.acs.org/doi/abs/10.1021/ar50112a001 View in LinkedIn
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linkedin post 2019-07-07 08:39:53

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CONFLICTED PERFECTION. "For some enzymes, there is going to be a conflict between changes that maximize catalytic effectiveness and changes that optimize control, and for these enzymes we may expect that some catalytic power has been sacrificed to the higher good of metabolic control." http://pubs.acs.org/doi/abs/10.1021/ar50112a001 View in LinkedIn
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linkedin post 2019-07-07 08:37:17

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ENZYMATIC SALTATIONS. "Enzymes are erroneously considered exquisitely precise and efficient molecular catalysts. Natural enzymes are also evolvable: in other words, they can migrate through mutational trajectories to arrive at alternative catalytic activities, sometimes in unexpected saltatory fashion." https://lnkd.in/d3RnrBP View in LinkedIn
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linkedin post 2019-07-06 05:08:52

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"PROTEIN CRYSTALS have been found to be more perfect as measured by their X-ray reflection rocking widths using collimated synchrotron radiation. The use of this parameter to assess the perfection of crystals grown by new methods, or in new environments such as microgravity, is important. Irradiation of protein crystals with X-ray almost invariably leads to a loss of perfection." (1988). https://lnkd.in/d5Vshm5 View in LinkedIn
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