GENE EDITOR. "With CRISPR, scientists can change, delete, and replace genes in any animal, including us." http://www.newyorker.com/magazine/2015/11/16/the-gene-hackers View in LinkedIn
PCR AND CRISPR are two innovations in the field of molecular biology that have irrevocably changed science, medicine and how we can view the future. PCR was invented in 1985, and CRISPR as a genomic tool in 2012. Due to the giant amount written about both, I chose to give them rather scant treatment, but inclusion by reference with enormous implications in this string of thoughts. View in LinkedIn
"CRISPR is the Model T of genetics. The Model T wasn’t the first car, but it changed the way we drive, work, and live. CRISPR has made a difficult process cheap and reliable. It’s incredibly precise. But an important part of the history of molecular biology is the history of editing genes.” http://www.newyorker.com/magazine/2015/11/16/the-gene-hackers View in LinkedIn
DUCHENNE'S. "In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Exon 23 deletion by CRISPR-Cas9 resulted in expression of the modified dystrophin gene, partial recovery of functional dystrophin protein in skeletal myofibers and cardiac muscle, improvement of muscle biochemistry, and significant enhancement of muscle force." https://lnkd.in/dWMSugr View in LinkedIn
HUMAN USE. "Last year, researchers in China shocked the world (and alarmed many in the scientific community) by modifying the DNA of human embryos. Now, as reported in Nature News, a research team led by Yong Fan at Guangzhou Medical University has used CRISPR, a powerful gene editing tool, to introduce HIV-resistance into the embryos." https://lnkd.in/dG3viYq View in LinkedIn
GEORGE CHURCH ON CRISPR, growing “human "organoids" or small clumps of human organ tissue in the lab, and use Crispr to give them genetic faults that cause disease. "This is a really big moment, because if you think something has a genetic component, you can prove it with Crispr, and then improve it with Crispr, or other therapies." https://lnkd.in/dvsfRzb View in LinkedIn
DNA MANIPULATION. "The Crispr procedure has been welcomed by geneticists in labs around the world because of its enormous potential. Unlike standard gene therapy, Crispr allows scientists to remove faulty genes from cells, or replace them with healthy ones. It can even correct single letter spelling mistakes in the DNA code." https://lnkd.in/dvsfRzb View in LinkedIn