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GEOMAGNETIC STORMS (GMS). "The cryptochrome genes are known primarily as key components of the circadian pacemaker, ultimately involved in controlling the expression of the hormone melatonin. Cryptochrome is identified as a clear candidate for mediating the effect of GMS on humans, demonstrating the prior existence of several crucial pieces of evidence.” (GMS = geomagnetic storms). https://lnkd.in/d6MM7qG View in LinkedIn

STROKE AND GEOMAGNETISM. “Overall, geomagnetic storms (Ap Index 60+) were associated with 19% increase in the risk of stroke occurrence (95% CI, 11%–27%). The triggering effect of geomagnetic storms was most evident across the combined group of all strokes in those aged 50%: moderate geomagnetic storms (60–99 Ap Index) were associated with a 27% (95% CI, 8%–48%) increased risk of stroke occurrence, strong geomagnetic storms (100–149 Ap Index) with a 52% (95% CI, 19%–92%) increased risk, and severe/extreme geomagnetic storms (Ap Index 150+) with a 52% (95% CI, 19%–94%) increased risk (test for trend, P

CONSERVED FUNCTION. “Despite this seeming diversity, cryptochromes are fundamentally similar in both structure and photochemistry enabling them to have the potential to detect not only light, but also redox state and geomagnetic field.” https://lnkd.in/ggMJNzs View in LinkedIn

CLEVELAND CLINIC subarachnoid hemorrhage study. "The NIS database contained 32,281 matching hospitalizations from 1988 to 2010. The acrophase (time point in the cycle of highest amplitude) for solar flux and for sunspots were coincident. The acrophase for aneurysmal SAH incidence was out of phase with solar activity determined by non-overlapping 95% confidence intervals (CIs).” https://lnkd.in/dEMKH_U View in LinkedIn

MAGNETIC SENSORS. “Cryptochromes (from the Greek κρυπτός χρώμα, "hidden colour") are a class of flavoproteins that are sensitive to blue light. They are found in plants and animals. Cryptochromes are involved in the circadian rhythms of plants and animals, and possibly also in the sensing of magnetic fields in a number of species.” https://lnkd.in/dKaQ-XV View in LinkedIn

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THE NUANCES. “A number of studies have established the effects of solar-geomagnetic activity on the human cardio-vascular system. These findings suggest that the heliophysical conditions before or after the admission affect the hazard ratio of lethal outcome; adjusting for clinical variables, these effects were stronger for women and older patients.” https://lnkd.in/dRix2gd View in LinkedIn

TIED TO THE COSMOS. “These findings add to the growing evidence that solar magnetic storm periodicities are mirrored by cyclic phase-locked rhythms of similar period length or lengths in human physiology and pathophysiology.” http://online.liebertpub.com/doi/abs/10.1089/ast.2010.0574 View in LinkedIn

PERIODICITY IN PATHOLOGY. “After determining that sunspot numbers and solar flux, which were not annually rhythmic, occurred with a prominent 10-year and a less-prominent 5.75-year periodicity during this 21-year study span, each biological data set was analyzed with the same curve-fitting procedures. All six annually rhythmic Pap smear-detected infectious, premalignant and malignant cervical epithelial pathologies showed strong 10-year and weaker 5.75-year cycles, as did all six self-measured, annually rhythmic, physiologic functions.” http://online.liebertpub.com/doi/abs/10.1089/ast.2010.0574 View in LinkedIn

BOTH EXTREMES. “Study linking environmental physical activity levels and the human medical data shows that human beings are predisposed to adverse health effects due to geomagnetic and cosmic ray activity variations and extremely high as well as extremely low values of GMA have health effects.” (GMA = geomagnetic activity). http://file.scirp.org/Html/6-8202044_31922.htm View in LinkedIn