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NEW POSSIBILITIES. “This suggests that chronotherapy, either in terms of external clock time or internal biological time, is underutilized and could be a major consideration to improve modern personalized medicine.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

CIRCADIAN BEST SELLERS. “Recent examination of 12 different organs in a mouse model demonstrates that the protein targets of 56% of the top-selling and World Health Organization essential medicines oscillate with circadian profiles.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

CLOCK BLINDNESS. “Currently, very few medications are administered based on the time of day in order to optimize beneficial effects or reduce side effects. Moreover, internal biological time (circadian phase) can differ between people in relation to external clock time, yet, since it is difficult to instantaneously assess circadian phase, there are virtually no medications currently administered based on internal biological time.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

MILIEU INTÉRIEUR “A medication’s effects are also dependent on receptor site availability and function, which can also be affected by the circadian system and by prior behaviors, such as exercise.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn

CLOCK AFFECTS ADME. “The sum of these daily circadian (24-h) and behavioral physiological patterns can therefore affect a medication’s bioavailability and duration of action through absorption, distribution, metabolism, and elimination.’ https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn