linkedin post 2020-07-24 04:00:24

linkedin post 2020-07-24 04:00:24

Uncategorized
EFFECTIVE DOSING. “To more effectively reduce nocturnal blood pressure and still counteract the morning surge in blood pressure, a number of studies have examined moving one or more antihypertensives from morning to bedtime dosing.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn
Read More
linkedin post 2020-07-24 03:58:58

linkedin post 2020-07-24 03:58:58

Uncategorized
BLOOD PRESSURE MEDS. “There is a well-documented 24-h pattern of blood pressure with a morning surge that may contribute to the observed morning increase in adverse cardiovascular events. Historically, antihypertensive therapy involves morning doses, usually aimed at reducing daytime blood pressure surges, but an absence of nocturnal dipping blood pressure is also associated with increased cardiovascular risk.” https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn
Read More

linkedin post 2020-07-25 05:19:12

Uncategorized
FAMOUS MASTER REGULATOR. “In some circumstances, selector genes may have the properties of master regulators—factors, such as the muscle-specific TF MyoD1, which alone can induce muscle fate when expression is induced in a variety of cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn
Read More

linkedin post 2020-07-25 05:17:51

Uncategorized
SELECTOR GENES. “In the contemporary view, selector genes are distinguished from other TFs because they play a deterministic role in “selecting” the overarching developmental program for germ layers, developmental fields, lineage compartments, individual metameric units, or cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn
Read More

linkedin post 2020-07-25 05:16:25

Uncategorized
GENE TRIGGERS. “Here, gain or loss of single-selector genes invoke a shift in the total program for creation of a morphological structure; for example, the stable transformation of a leg into an antenna through loss of the homeobox (Hox) gene Antennapedia.” https://lnkd.in/dfCi2dc View in LinkedIn
Read More

linkedin post 2020-07-26 07:38:43

Uncategorized
COMPLEX STITCH WORK. “For example, feed-forward and feedback loops stabilize gene expression programs long after the initial stimulus that initiated them has faded, and histone and DNA marks that regulate chromatin structure also profoundly contribute to gene expression status and potential.” https://lnkd.in/dfCi2dc View in LinkedIn
Read More

linkedin post 2020-07-26 07:37:46

Uncategorized
NON-GENETIC TRIGGERS. “The general or specific state of a GRN can be “remembered,” to the extent of being inherited by daughter cells across cell divisions, referred to as epigenetic memory. Many mechanisms contribute to epigenetic memory.” (GRN = gene regulatory networks). https://lnkd.in/dfCi2dc View in LinkedIn
Read More