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NETWORKS OF SWITCHES. “In essence, selector genes are factors that are involved in switching functions within the GRN that impact on cell lineage or morphogenetic fate. Some of these may have the property ascribed to master regulators in being able to cell-autonomously affect a network switch.” (GRN = gene regulatory networks). https://lnkd.in/dfCi2dc View in LinkedIn

FAMOUS MASTER REGULATOR. “In some circumstances, selector genes may have the properties of master regulators—factors, such as the muscle-specific TF MyoD1, which alone can induce muscle fate when expression is induced in a variety of cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

SELECTOR GENES. “In the contemporary view, selector genes are distinguished from other TFs because they play a deterministic role in “selecting” the overarching developmental program for germ layers, developmental fields, lineage compartments, individual metameric units, or cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

GENE TRIGGERS. “Here, gain or loss of single-selector genes invoke a shift in the total program for creation of a morphological structure; for example, the stable transformation of a leg into an antenna through loss of the homeobox (Hox) gene Antennapedia.” https://lnkd.in/dfCi2dc View in LinkedIn

METAMORPHOSIS. “Garcia-Bellido formulated the “selector gene” hypothesis to explain the effects of gene mutations that famously convert one body part into another.” https://lnkd.in/dfCi2dc View in LinkedIn

COMPLEX STITCH WORK. “For example, feed-forward and feedback loops stabilize gene expression programs long after the initial stimulus that initiated them has faded, and histone and DNA marks that regulate chromatin structure also profoundly contribute to gene expression status and potential.” https://lnkd.in/dfCi2dc View in LinkedIn

PRIMARY DRIVERS. “These dynamic changes to the structure of networks during development are reflected in the regulation of gene batteries, sets of genes that define the terminal gene expression program and identity of a cell.” https://lnkd.in/dfCi2dc View in LinkedIn

NON-GENETIC TRIGGERS. “The general or specific state of a GRN can be “remembered,” to the extent of being inherited by daughter cells across cell divisions, referred to as epigenetic memory. Many mechanisms contribute to epigenetic memory.” (GRN = gene regulatory networks). https://lnkd.in/dfCi2dc View in LinkedIn

CONTROL NODES. “Analogous to electrical circuits, deployment or detachment of subcircuits can be regulated by GRN “switches.” Switches could be signal or TF dependent, or may involve specific modifications of chromatin that affect accessibility of TFs to DNA elements.” (TF = transcription factors). (GRN = gene regulatory networks). https://lnkd.in/dfCi2dc View in LinkedIn

COLLABORATIVE CONTROL. “Therefore, in network terms, it is both the internal GRN and the dynamic influences of external signaling that determines regulatory and lineage states.” (GRN = gene regulatory networks). https://lnkd.in/dfCi2dc View in LinkedIn