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LAYERS OF CONTROL. “As such, kernel TFs represent network hubs and tampering with them has catastrophic consequences for development. The kernel then engages subcircuits that establish regional regulatory states controlling, for example, cell division, epithelial state, and/or migration.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

BRANCHING FATES. “Asymmetric cell division—the division of cells into daughters that have different cell fates—also plays a central role in cell fate determination in stem and progenitor cell populations through the asymmetric partitioning of deterministic components, including ancestral “template” DNA strands, to individual daughter cells.” https://lnkd.in/dfCi2dc View in LinkedIn

FRAGMENT FROM NATURE continues from last weekend and ends this weekend on the theme of genetic regulatory networks. These complex regulatory systems are key to the central processes in biology of development and metamorphosis, and have evolved a hierarchical system of switches that control the output of the genome. DNA on its own does nothing, but in concert with regulatory and transcription factors make the orchestra that we call life. View in LinkedIn

TUMOR TRIGGERS. “Dysregulation of clock genes promotes tumorigenesis through mechanisms that include the cell cycle, DNA damage, and metabolism.” https://lnkd.in/dT2NKaY View in LinkedIn

Transformation of leaf form during maturation. It begs the functional question, whose answer is not obvious. View in LinkedIn

TO START AT THE BEGINNING. “To develop cancer chronotherapy, the first crucial step is to understand the roles of clock genes in cancer. The mammalian circadian machinery is controlled by two main transcriptional/translational auto-regulatory feedback loops that involve 14 core clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

NEW WAY FORWARD. “Cancer chronotherapy appears to offer the potential to improve current cancer treatments and to refine the development of new anti-cancer drugs.” https://lnkd.in/dT2NKaY View in LinkedIn

TIMING MATTERS. “Early clinical trials have suggested significant clinical benefits of specific circadian timing of chemotherapy or radiotherapy by combination with vinblastine, cyclophosphamide, and methotrexate or 5-fluorouracil.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND SURVIVAL. “Disruption of the circadian rhythm is associated with cancer development and poor prognosis. For example, patients with metastatic colorectal cancer who have normal circadian rhythms have a 5-fold higher survival rate than patients with severely disrupted circadian rhythms.” https://lnkd.in/dT2NKaY View in LinkedIn

APPLIED STUDY. “Our study provides a comprehensive analysis of the circadian clock across different cancer types and highlights potential clinical utility of cancer chronotherapy.” https://lnkd.in/dT2NKaY View in LinkedIn