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CLOCK GENES AND CANCER. “These results suggest that genetic alterations of clock genes play functional roles in cancer.” https://lnkd.in/dT2NKaY View in LinkedIn

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MUTATED CLOCK GENES. “To further determine genetic alterations of clock genes in human cancer, we analyzed non-silent mutations of clock genes across cancer types. We observed that mutation frequency is relatively low for core clock genes, with fewer than five mutations in the majority of samples (Figure 3B). However, mutations of core clock genes were associated with patients' overall survival.” https://lnkd.in/dT2NKaY View in LinkedIn

Ancient pentagon skewed by street constraints, not fully corrected by internal editing. View in LinkedIn

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DRUGS LINK TO GENES. “We identified 2,059 significant correlation pairs between drug sensitivity and transcriptional expression of clock genes (Figure S7B). Among these, sensitivity to 82 anti-cancer drugs significantly correlated with at least 10 clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

BROAD STUDY. “To further evaluate the potential effects of clock genes on drug response, we analyzed the correlation between drug sensitivity of 265 anti-cancer drugs and transcriptional expression of 51 clock genes across 1,080 cancer cell lines from GDSC using the Z score as described previously.” https://lnkd.in/dT2NKaY View in LinkedIn

DRUG TARGETS. “Many clinically actionable genes are targeted by anti-cancer drugs. Thus, following circadian timing for drug administration may largely improve the efficacy of a drug and reduce its toxicity.” https://lnkd.in/dT2NKaY View in LinkedIn

CLINICAL IMPLICATIONS. “Our results suggest diverse effects of clock genes on clinically actionable genes. Therefore, the significant interactions between clinically actionable genes and clock genes may affect drug responses, and the circadian timing should be necessarily considered in cancer therapy.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENE LINKS. “We observed that 145 of 154 (94.2%) clinically actionable genes have significant correlations, with at least one clock gene in more than five cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn