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CENTRAL ROLE. “We observed that paralog clock genes could play synergistic or different roles to alter oncogenic pathways, further suggesting a complex regulation of clock transcriptional loops.” https://lnkd.in/dT2NKaY View in LinkedIn

CONFIRMED FINDINGS. “We observed cancer-specific patterns for several genes across different cancer types, consistent with previous finding that genetic elements may play different roles in different tumor environments. Furthermore, the expression changes in clock genes are highly associated with the activity of oncogenic pathways.” https://lnkd.in/dT2NKaY View in LinkedIn

EXPANDING KNOWLEDGE. “Supporting the development of cancer chronotherapy, we revealed pervasive transcriptional dysregulation of clock genes across different cancer types, including changes in clock genes that are not well-characterized.” https://lnkd.in/dT2NKaY View in LinkedIn

TODAY, nearly half of the world lives in cities and modern children spend less than half the time that their parents did playing outside. Modern travel means that we whisk past nature on our way to places. We are living lives disconnected from the natural world and are forgetting our deep connections to this place and state of being. View in LinkedIn

APPLIED RESEARCH. “Our study provides a comprehensive analysis of the circadian clock across different cancer types and highlights potential clinical utility of cancer chronotherapy.” https://lnkd.in/dT2NKaY View in LinkedIn

MY EPITAPH. "The more I study nature, the more I become impressed […] that the contrivances and beautiful adaptations [acquired through natural selection] transcend in an incomparable degree [those] which the most fertile imagination of the most imaginative man could suggest with unlimited time at his disposal." (Charles Darwin). https://lnkd.in/eykUy37 View in LinkedIn

LARGE SCALE STUDIES. “We identified global interactions between clock genes and CAGs through co-expression, protein-protein interaction, and ChIP-seq data. This was further supported by the large-scale pharmacogenomic data from CTRP and GDSC that clock genes could largely affect anti-cancer drug sensitivity in cancer cell lines.” https://lnkd.in/dT2NKaY View in LinkedIn

Marly limestone in building materials in Girona, including the several types of silt inclusion colors, and larger coin shell fossils that are among the biological sources of the limestone itself. These fossils are a major topic by themselves. View in LinkedIn

TRANSITION TO A NEW TOPIC. This is now the end of the cancer chronobiology section, and chronobiology in general, and tomorrow we transition into a section that considers plants, specifically, how plants make decisions, and how they plan. While some have called this ‘plant intelligence’, the term itself has been ill-chosen, and caused a firestorm of controversy. But regardless, there is strong evidence that plants have sophisticated abilities to make decisions, as we shall see. View in LinkedIn