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CAUSE OF ZIG-ZAG. The unusual backbone is associated with guanosine residues which have an unusual conformation. NMR studies in solution have shown that purine residues can adopt the syn and anti conformations with equal ease. Another difference is found in the pucker of the sugar ring.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

ZIG-ZAG ALTERNATION. “The left-handed helix has the phosphates arranged in a zig-zag array; hence the name Z-DNA. The same Z structure has been found in crystals of tetramers d(CpGpCpG) as well as in other hexamer crystals.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn

FRAGMENT FROM NATURE continues from last weekend and concludes this weekend on a paper from the early days of untangling the structure of DNA, by Professor Alexander Rich from MIT, featuring the unraveling of left handed DNA. The story is written in crystal clear language, with unyielding logic, an historical milestone. https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn