linkedin post 2021-06-05 04:56:31

linkedin post 2021-06-05 04:56:31

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GENE CONTROL. “Extensive studies have been carried out which have shown that methylation of DNA is generally associated with turning off transcription; conversely, demethylation is associated with the initiation of transcription or the expression of the gene.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-05 04:54:22

linkedin post 2021-06-05 04:54:22

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STABILIZERS. “The major conclusion reached from these studies is that the equilibrium between the B form and Z form of poly(dG-dC) is strongly influenced by cations and by the substituents which are attached to the polymer. A number of these substituents profoundly influence the equilibrium between the two forms and favor the Z-DNA conformation.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-05 04:53:30

linkedin post 2021-06-05 04:53:30

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THE STABILITY EXPLANTATION. “Since purine nucleotides can adopt the syn conformation more readily than pyrimidine nucleotides, it is reasonable to believe that the Z conformation will be favored in sequences with alternating purines and pyrimidines.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-05 04:52:18

linkedin post 2021-06-05 04:52:18

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ORIENTATION SWITCH. “One consequence of these differences in conformation is that the bases in Z-DNA have a different orientation relative to the sugar phosphate backbone than they do in B-DNA. In essence, the bases must "flip over" in order to go from one form to the other.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-06 03:48:49

linkedin post 2021-06-06 03:48:49

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SURPRISE FINDING. “It has been shown that Z-DNA can exist in the same molecule with B-DNA. This was shown by cloning oligo(dG-dC) into plasmids and then isolating segments containing both the plasmid DNA and the oligo(dG-dC).” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-06 03:47:33

linkedin post 2021-06-06 03:47:33

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THE FACTORS. “Because of increased phosphate-phosphate repulsion forces the left-handed helical structure is inherently less stable than B-DNA in a physiological salt solution. In view of the equilibrium between the two forms, it is clear that a number of components in the environment could stabilize Z-DNA.” https://link.springer.com/content/pdf/10.1007/978-94-009-7052-6.pdf View in LinkedIn
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linkedin post 2021-06-06 03:58:27

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THE ILLUSION. “The biological domain is organized as an interdependent hierarchy of processes, which are stabilized and actively maintained at different timescales. Even entities that intuitively appear to be paradigms of things, such as organisms, are actually better understood as processes.” https://lnkd.in/dWEbH7i View in LinkedIn
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linkedin post 2021-06-06 03:57:11

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SO ENDS this second weekend on DNA handedness, and the importance of DNA methylation. Since this paper was published in 1982, DNA methylation has been found critical in epigenetic phenomena, triggered by factors like diet, environment and exercise, over-riding hard core fixed gene effects, sometimes in only weeks. https://lnkd.in/de3XS4Q View in LinkedIn
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