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CLINICAL UTILITY. “We hope for the application in cancer genes, but at first the genes on which the measurements can be made must be identified by genetic experts. However, we provide the tool for the terminal measurements incorporated into more complex biophysical experiments.” https://www.mdpi.com/2073-8994/12/8/1214/htm View in LinkedIn

THE FILTER. “With our model we are looking for the effective change of topology of proteins, i.e., the stable structures of noncoding DNA binding to genes; this procedure selects only certain structures that can be detected.” https://www.mdpi.com/2073-8994/12/8/1214/htm View in LinkedIn

NEW TOOL. “We can train our algorithm on the different versions of the genes, on normal genes with non-modified sequences of nucleotides or on their mutated versions as cancer genes, which code different structures than the normal ones.” https://www.mdpi.com/2073-8994/12/8/1214/htm View in LinkedIn

TEMPORAL VIEW. “The incorrect amino acids can be inserted into a protein molecule, the synthesis of a protein can be prematurely terminated, and the mutated codon can code the same amino acid as the non-mutated codon. As a consequence of DNA constant change, the difference between the mutated and normal versions of the gene changes over time.” https://www.mdpi.com/2073-8994/12/8/1214/htm View in LinkedIn

GENE-LEVEL MUTATIONS. “It may be a swapping of one nucleotide for another one, a deleting or omitting of a specific nucleotide from the strand, or an inserting of an extra nucleotide into the replication strand. Besides the single codon substitutions, on the level of codons there exist other categories of mutations.” https://www.mdpi.com/2073-8994/12/8/1214/htm View in LinkedIn