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CHEMICAL SIGNALS. “Unlike electronic digital circuits, the components in a biological circuit are not connected by wires, and the flow of biological information has to depend on their specific chemical interactions to avoid cross-talk.” https://lnkd.in/dsEUY4ZP View in LinkedIn

REDUCED NOISE. “The circuit chassis compatibility assays reported here (Fig. 6) indicate that the use of orthogonal and exogenous gene elements for a synthetic circuit in a chassis help to minimize the potential unintended interactions between the circuit and host genetic programmes.” https://lnkd.in/dsEUY4ZP View in LinkedIn

SCALABLE. “Orthogonal parts and modules, such as the AND gate engineered in this study, are important for the compatibility and scalable design of large gene circuits comprising many components. Orthogonality implies that the newly added parts and modules should not cross-talk with those present in the engineered biological systems as well as the host genetic background.” https://lnkd.in/dsEUY4ZP View in LinkedIn

STRATEGY. “The obtained transfer functions of the logic gates implemented here can be used to simulate the behaviour of larger integrated devices or systems when the context in which they are placed is preserved. Alternatively, biological components might be insulated physically and genetically to let them act more stably and predictably in different contexts.” https://lnkd.in/dsEUY4ZP View in LinkedIn

My tiny crab who lives on an anemone is filter feeding with his extended mouthpiece. View in LinkedIn

REPRODUCIBILITY. “However, the behaviours of assembled logic circuits were modelled predictably from components when characterized in the same abiotic and genetic context as required for their final operation, implying that, to achieve predictable circuit engineering, individual parts and modules should be in-context characterized to eliminate or reduce any behavioural variations arising from differences in context.” https://lnkd.in/dsEUY4ZP View in LinkedIn

BEYOND THE SKULL. “As Lewis Carroll's Alice might have phrased it: ‘You're nothing but a pack of neurons’.’ But it seems to me that this is not so astonishing a statement for a scientist to make. Isn't this what reductionist science has always believed?”" " https://lnkd.in/d5mx5w22 View in LinkedIn

MILIEU. “The results obtained show that both the abiotic and genetic contexts (for example, chassis, medium, temperature and embedded sequence context) in which the parts and modules are placed have a significant impact on their functionality.” https://lnkd.in/dsEUY4ZP View in LinkedIn

BLACK HOLES AND ANTIMATTER. “Black holes are predicted to repel antiparticles and isoduallight due to an expected very strong gravitational repulsion. This occurrence has led Santilli to the initiation of the search for the emission of isoduallight by the black hole expected at the center of our Milky Way via the use of pairs of Galileo and Santilli telescopes.” https://lnkd.in/drUkrKWz View in LinkedIn

APPROACH. “Here the genetic logic devices were constructed using a forward engineering approach consisting of quantitative in-context characterization, computational modelling, construction and testing.” https://lnkd.in/dsEUY4ZP View in LinkedIn