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THE PROMISE OF POOP. "Gastroenterologist Thomas Borody...who since 1988 has performed fecal transplants in more than 3000 patients, suffering not just from C. difficile but also from irritable bowel syndrome; inflammatory bowel syndrome; constipation; arthritis; and sacroiliitis, an inflammation of the sacroiliac joint." https://lnkd.in/ebyCPji View in LinkedIn

THIS CONCLUDES this weekend's fragment in nature on Fecal Microbiota Treatments. This approach is a revival of old methods, similar to renewed interest in phage therapy. Equally, stem cell therapies are opening new doors in disease treatments. View in LinkedIn

FMT "heralds the delayed adolescence of a broad and exciting new branch of human therapeutics." 2013 Editorial in the prestigious New England Journal of Medicine. A sea change. https://lnkd.in/e92WcxV View in LinkedIn

INFLAMMATORY BOWEL DISEASE AND FMT. "FMT is a safe but variably efficacious treatment for IBD. More randomized controlled trials are needed." https://lnkd.in/e9devNP View in LinkedIn

AN OLD THERAPY COMES OF AGE. Impediments to FMT include: "It is aesthetically unappealing, it is logistically challenging (in terms of harvesting and processing suitable donor material), and there is a lack of efficacy data from randomized, controlled trials." https://lnkd.in/e92WcxV View in LinkedIn

"SYSTEMATIC REVIEW: faecal microbiota transplantation in the management of inflammatory bowel disease. Whilst the available evidence is limited and weak, it suggests that faecal microbiota transplantation has the potential to be an effective and safe treatment for IBD, at least when standard treatments have failed. Well-designed randomised controlled trials are required to investigate these findings." https://lnkd.in/edRQD5H View in LinkedIn

FECAL TRANSPLANTS (FMT). "The rationale behind FMT is simple: antibiotics and other factors disrupt the normal balance of colonic flora and reduce "colonization resistance", allowing pathogenic C. Difficle strains to grow...by reintroducing flora via donor feces, the imbalance can be corrected, the cycle interrupted, and normal bowel function re-established." https://lnkd.in/erygCxw View in LinkedIn

C. DIFFICILE FMT REVIEW. "In 317 patients treated across 27 case series and reports, FMT was highly effective, showing disease resolution in 92% of cases. Effectiveness varied by route of instillation, relationship to stool donor, volume of FMT given, and treatment before infusion. Death and adverse events were uncommon." https://lnkd.in/eymWM_R View in LinkedIn

C. DIFFICILE. "Fecal microbiota transplantation (FMT) is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured." Cured with a single treatment. https://lnkd.in/erygCxw View in LinkedIn

"CLOSTRIDIUM DIFFICILE INFECTION is increasing in incidence, severity and mortality. Treatment options are limited and appear to be losing efficacy." https://lnkd.in/erygCxw View in LinkedIn