Category: Uncategorized

ANCIENT PROCESSES. "Specific gene silencing has been shown to be related to two ancient processes, cosuppression in plants and quelling in fungi, and has also been associated with regulatory processes such as transposon silencing, antiviral defense mechanisms, gene regulation, and chromosomal modification." https://lnkd.in/eity6gi View in LinkedIn

PRION PROTEIN FOLDING, or its 3D structure, conveys enough information to change a normal cellular protein into an infectious prion particle. As such, it is a protein gene, a rather controversial concept. https://lnkd.in/e3uKvuP View in LinkedIn

VIRAL SUPPRESSORS OF RNA SILENCING and the inevitable counter-defense. "VSRs efficiently inhibit host antiviral responses by interacting with the key components of cellular silencing machinery, often mimicking their normal cellular functions." https://lnkd.in/eaZgcEZ View in LinkedIn

MULTIPLE PHASES = INFORMATION. "Anything is a source of information if it has a range of possible states, and one variable carries information about another to the extent that their states are physically correlated." https://lnkd.in/espyFHA View in LinkedIn

VERY UNUSUAL. "The infection and replication of viruses in the host induce diverse mechanisms for combating viral infection. One of the best-studied antiviral defence mechanisms is based on RNA silencing. Consistently, several viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera, which are surprisingly diverse within and across kingdoms, exhibiting no obvious sequence similarities." https://lnkd.in/eaZgcEZ View in LinkedIn

CHANGES OF STATE. "For Shannon, anything is a source of information if it has a number of alternative states that might be realized on a particular occasion. And any other variable carries information about the source of its state is correlated with that of the source." This is at the heart of programmable inert matter. https://lnkd.in/eHPWXiJ View in LinkedIn

SILENCING CONSERVED. "RNA silencing is a conserved sequence-specific gene regulation system, which has an essential role in the development and maintenance of genome integrity in a wide variety of organisms. In higher plants and insects, RNA silencing also operates as an adaptive inducible antiviral defence mechanism." (Good review). https://lnkd.in/eaZgcEZ View in LinkedIn

NOT JUST GENES. "Single proteins contain internal information channels" as shown by biological sender-receiver analysis in single allosteric molecules." https://lnkd.in/eJc-Z-m View in LinkedIn

"THE SILENCING of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to target homologous mRNA. The resulting phenotypes either are identical to those of genetic null mutants or resemble an allelic series of mutants." https://lnkd.in/eity6gi View in LinkedIn

GENES are the modern temple of biological information processing. However, genes are not the only source of biological molecular information. Most, if not all, biological molecules need to receive, process and transmit information in order to function. Often, this is effected by electron chains, conformational changes, relations with structured water, and other types of molecular collaboration. View in LinkedIn