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PLACENTAL PATHOLOGIES. "We could show that reduced Syncytin-1 expression in placental syndromes was due to an epigenetic hypermethylation of the entire promoter region of ERVW-1. We propose that a promoter hypermethylation occurs in these pathological placentae due to the fact that DNA-methyltransferases, which are responsible for the setting of these epigenetic marks, are overexpressed." https://lnkd.in/e8X7a46 View in LinkedIn

PROBLEM PREGNANCIES. "Aberrations during this cell-fusion process are associated with Intrauterine Growth Restriction (IUGR), Preeclampsia (PE) and High Elevated Liver and Low Platelets (HELLP) Syndrome. Syncytin-1, the envelope gene of the human Endogenous Retrovirus ERVW-1, is one of the most important genes involved in cell-fusion and showed decreased gene expression during these pathological pregnancies." https://lnkd.in/e8X7a46 View in LinkedIn

ALTERNATIVE VIEW. "A virus first perspective is presented as an alternative hypothesis to explain the role of various endogenized retroviruses in the origin of the mammalian placenta." https://lnkd.in/etdQ9rN View in LinkedIn

VIRAL DOMINANCE. "So powerful and ancient are viruses, that I would summarize their role in life as ‘Ex Virus Omnia’ (from virus everything)." https://lnkd.in/etdQ9rN View in LinkedIn

OTHER MEMBRANE FUSION ROLES. "Syncytin-1 and Syncytin-2...these ERV proteins, in addition to their localization at the cell surface of cytotrophoblasts, are also incorporated on the surface of various extracellular microvesicles, including exosomes." https://lnkd.in/eNxap6v View in LinkedIn

OTHER MEMBRANE FUSION ROLES. "Syncytin-1 and Syncytin-2...these ERV proteins, in addition to their localization at the cell surface of cytotrophoblasts, are also incorporated on the surface of various extracellular microvesicles, including exosomes." https://lnkd.in/eNxap6v View in LinkedIn

MID-GESTATIONAL TRANSITION. "The transition is not simply due to the expansion of an individual cell type, but appears to be a global shift in gene usage in the absence of major morphological change." https://lnkd.in/eN_bZTg View in LinkedIn

THOUSANDS OF GENES. "A comprehensive expression profiling encompassing the full lifetime of the murine placenta from embryonic day 8.5, at the time of chorioallantoic fusion, until postnatal day 0 (P0), just after birth, uncovered a striking molecular transition occurring during mid-gestation. This transition separates two phases of placentation that are distinct on a molecular level and encompasses thousands of genes." https://lnkd.in/eN_bZTg View in LinkedIn

ROLE IN ALS. "Ancient retroviral genes found to contribute to ALS." https://lnkd.in/ewhe2gK View in LinkedIn

"INNOVATORS rarely come up with new ideas; instead, they convert old ideas into new ones, adapting them from one context to another. https://lnkd.in/ekkzkwr View in LinkedIn