linkedin post 2016-09-26 05:01:36

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ANCIENT VIRAL BITS AND PIECES. "By far the dominant type of nongenic DNA are transposable elements (TEs), including various well-described retroelements such as Short and Long Interspersed Nuclear Elements (SINEs and LINEs), endogenous retroviruses, and cut-and-paste DNA transposons." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn
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linkedin post 2016-09-28 05:20:09

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MAJORITY OF GENES ALTERNATIVELY SPLICE. "At least 75% of roughly 30,000 human genes undergo alternative splicing to encode two or more splice isoforms, with striking variation across tissue types and developmental stages." http://bitesizebio.com/10148/what-is-alternative-splicing-and-why-is-it-important/ View in LinkedIn
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linkedin post 2016-09-27 05:50:56

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ALTERNATIVE SPLICING "is a process by which exons or portions of exons or noncoding regions within a pre-mRNA transcript are differentially joined or skipped, resulting in multiple protein isoforms being encoded by a single gene. This mechanism increases the informational diversity and functional capacity of a gene during post-transcriptional processing and provides an opportunity for gene regulation." http://bitesizebio.com/10148/what-is-alternative-splicing-and-why-is-it-important/ View in LinkedIn
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linkedin post 2016-09-27 05:46:15

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INTRON REMOVAL. Genetic "information is transcribed from DNA into a messenger RNA (mRNA) template by a process called transcription. However, in eukaryotes, before the mRNA can be translated into proteins, non-coding portions of the sequence, called introns, must be removed and protein-coding parts, called exons, joined by RNA splicing to produce a mature mRNA." http://bitesizebio.com/10148/what-is-alternative-splicing-and-why-is-it-important/ View in LinkedIn
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linkedin post 2016-09-27 05:44:26

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INTRONS HOUSE MOBILE ELEMENTS. "About 40% of the human genome is comprised of intronic regions; however, this figure is likely an overestimate as it includes all annotated events. It is also important to note that a large fraction of TEs and repetitive elements are found in introns." (TE = transposable elements). http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn
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linkedin post 2016-09-27 05:41:05

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INTRONS. "In some genes, not all of the DNA sequence is used to make protein. Introns are noncoding sections of an RNA transcript, or the DNA encoding it, that are spliced out before the RNA molecule is translated into a protein. The sections of DNA (or RNA) that code for proteins are called exons." https://lnkd.in/eJuUs5M View in LinkedIn
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linkedin post 2016-09-27 05:39:08

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SLOWLY EXPANDING INFORMATION. "Others, such as telomeric- and centromeric-associated repeats, play critical roles in chromosomal maintenance. Despite this, there is currently no evidence that the majority of highly repetitive elements are functional." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn
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linkedin post 2016-09-29 05:42:57

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SMALL FRACTION CONSERVED. "Several analyses of sequence conservation between humans and other mammals have found that about 5% of the genome is conserved. It is possible that an additional 4% of the human genome is under lineage-specific selection pressure; however, this estimate appears to be somewhat questionable." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn
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