Month: September 2022

INTRON CONCENTRATION. “We found that introns of lincRNA genes contain the highest fraction of TES, followed by exons. The promoters of the lincRNAs contain the lowest fraction of TES but the largest fraction of ancient TES that are conserved between primates and rodents.” (TES = Transposable element-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

EXON AND PROMOTOR CONCENTRATION. “The content of TES in lincRNA genes is substantially greater than in protein-coding genes, particularly in exons and promoter regions.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

MAJOR PLAYERS. “These results are compatible with the view that TEs are major contributors to the origin and evolution of lincRNAs.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

EVOLUTIONARY CONTRIBUTION. “Thus, it has been suggested that TES divide lincRNAs into classes and have contributed to lincRNA evolution and function by conferring tissue-specific expression from extant transcriptional regulatory signals.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

EVOLUTIONARY CONTRIBUTION. “Thus, it has been suggested that TES divide lincRNAs into classes and have contributed to lincRNA evolution and function by conferring tissue-specific expression from extant transcriptional regulatory signals.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

VIRAL ENRICHMENT. “Here, we add another facet to these observations by showing that the promoter regions of lincRNAs are specifically enriched for ancient TES. This finding indicates that not only have many lincRNA genes evolved before the radiation of primates and rodents but also that at least some features of their regulation were already established at that time through TE insertion.” (TES = TE-derived sequences; lincRNA = long intergenic non-coding RNA; TE = transposable element). https://lnkd.in/dwuaM5f View in LinkedIn

PEPTIDE DEBATE. “The possibility that some lincRNA genes encode short peptides that are translated, perhaps in a tissue-specific manner, is the subject of an ongoing debate.” (lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

PEPTIDE PRODUCTION. “It is extremely hard to rule out such a role for a fraction of purported lincRNAs.” (lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn

FUNCTIONAL DOMAINS. “Johnson and Guigo (2014) have proposed that exonic TES comprise functional domains of lncRNAs that they dubbed repeat insertion domains of LncRNAs (RIDLs).” (TES = TE-derived sequences). https://lnkd.in/dwuaM5f View in LinkedIn

REPURPOSED VIRAL FOSSILS. “These examples are likely to reflect a more general phenomenon of exaptation and/or domestication during lncRNA evolution whereby TES are employed as DNA-, RNA-, and protein-binding domain/motifs.” (lincRNA = long intergenic non-coding RNA). https://lnkd.in/dwuaM5f View in LinkedIn