Month: September 2022

GROWING LIST. "This project led to a catalog of lncRNAs with 10000 genes producing 15000 lncRNAs. Very recently, 58648 lncRNAs were identified by using the TCGA database, of which 79% were previously unannotated." (lncRNA = long non coding RNA). https://lnkd.in/d8ucprw View in LinkedIn

GENETIC DARK MATTER. "Only a very limited number of lncRNAs (1%) have been well characterized functionally in humans. Major challenges of the next 10 years remaining are identification, mapping of all lncRNAs belonging to the human genome, and their functional characterization." (lncRNA = long non coding RNA). https://lnkd.in/d2sxUZQ View in LinkedIn

PART OF CHAIN? "Although their mechanisms of action are better known, it is still possible that lncRNAs are rather downstream products of particular chromatin structures or deregulated transcriptional processes." https://lnkd.in/d2sxUZQ View in LinkedIn

OVERLAP. "A large proportion of eukaryotic transcription is bidirectional, producing ncRNAs that can overlap with the transcription of protein coding genes. They interact as well as compete for a target on the mRNA." (ncRNA= Non coding RNA). View in LinkedIn

Reference for uncited quotes in this string: https://lnkd.in/dwhweFC http://www.sciencedirect.com/science/article/pii/S0925443914000714 View in LinkedIn

mRNA GENES. "Genes for microRNAs are located on all chromosomes and are mostly found within stretches of DNA between clusters of genes, in introns of non-coding or coding genes, as well as in exons of noncoding genes. Many microRNAs are transcribed and regulated independently, and use their own transcription initiation regions." View in LinkedIn

mRNA ACTION IN NUCLEUS. "Although microRNAs are known to mediate post-transcriptional gene silencing in the cytoplasm, recent evidence suggests that at least some fraction of mammalian microRNAs may also activate or inhibit gene repression at the transcriptional level in the nucleus." View in LinkedIn

DAMPENING PHENOTYPE. "By coordinating and regulating many genes, microRNAs are well-suited to act as stabilizers of gene expression networks and to prevent extreme variations in phenotype due to intrinsic and extrinsic disturbances." View in LinkedIn

mRNA AND NUANCING. "Although most of the microRNAs have been implicated in gene silencing, either fully or partially, they are also involved in the transcriptional activation and co-activation of many genes. In other words, microRNAs collectively fine-tune gene expression." View in LinkedIn

MAJOR GENE REGULATORS. "The number of known functional microRNA genes has been estimated to be ~ 1100, a number comparable to those of transcription factors or RNA binding proteins (RBPs), and over one third of all known human genes are probably regulated by them." View in LinkedIn