Month: September 2022

EXPRESSION. "Whereas, some microRNAs are ubiquitously expressed, others have an expression pattern that depends on the developmental stage or on the cell type." View in LinkedIn

Reference for following uncited quotes: Non-Coding RNAs: A Dynamic and Complex Network of Gene Regulation" "Munshi A, Mohan V and Ahuja YR View in LinkedIn

EPIGENETIC MEDIATORS. "MicroRNAs have an important role in the dynamic interplay between the environment and genome, including both genetic and epigenetic processes." View in LinkedIn

EPIGENETIC CROSSTALK. "Paramutation is the epigenetic transfer of information from one allele of a gene to another, without sequence change, to establish a state of gene expression that is inherited.” View in LinkedIn

PARAMUTATION. "Paramutation has been found at several loci in maize, and at fewer loci in other species, including mice and humans. MicroRNAs contribute to the mechanism of this trans-generational inheritance, establishment and maintenance of paramutations." View in LinkedIn

MOBILITY. "A key feature of microRNAs is their ability to spread from cell to cell. Small RNA mobility is highly regulated both developmentally and in response to physiological and environmental change. Such non-cell autonomous gene repression has been characterized extensively in both plants and animals." View in LinkedIn

PLANT mRNA MOBILITY. "Recently, a large population of messenger RNA (mRNA) was shown to be able to travel between plant organs via sieve elements as a putative long-distance signalling molecule. Here we show that experimental mRNA mobility data in Arabidopsis can be explained by transcript abundance and half-life. This suggests that the majority of identified mobile transcripts can be accounted for by non-sequence-specific movement of mRNA from companion cells into sieve elements." https://lnkd.in/dY_ZChz View in LinkedIn

PHLOEM TRAVEL. "Acclimation to environmental conditions is vital for plants. At the whole-plant level, this is aided by long distance signalling between organs, which is important both for plant development and defence responses. Long-distance signalling molecules can be transported through the phloem, in enucleated cells called sieve elements. mRNA is also able to move in sieve elements, and some mobile transcripts have been shown to give rise to developmental differences at distal locations." https://lnkd.in/dY_ZChz View in LinkedIn

HIGHLY MOBILE mRNA. "mRNA moves between host and parasitic plants as well as between heterografts. Recently a pioneering grafting approach identified a large population of 2,006 mobile mRNA species that were able to move between roots and shoots in grafted Arabidopsis ecotypes. Interestingly, these data suggest that a large percentage of mRNA can move against the direction of phloem flow." Enormous wow on many levels. https://lnkd.in/dY_ZChz View in LinkedIn

FRAGMENT FROM NATURE for two weekends is a contemplation of the vitamin C gene. This metabolically important gene has been variously lost and regained in various species during evolution, and where ample dietary vitamin C is available, it appears to have little fitness consequences. It is a reminder that the evolutionary process is quite random, faltering, the acts of a blind impulsive child forever tinkering with an immense machine. View in LinkedIn