linkedin post 2018-01-30 05:53:18
NATURAL SELECTION acts on genes that code proteins. Does it also act on the non-coding genome? View in LinkedIn
linkedin post 2018-01-30 05:54:23
FOOTPRINTS OF SELECTION. "Natural selection leaves imprints on DNA, offering the opportunity to identify functionally important regions of the genome." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-01-31 05:38:47
ADAPTIVE SIGNPOSTS. "The rapid accumulation of genome sequences and the development of powerful statistical methods, to detect signatures of adaptation, provide us an unprecedented opportunity to increase our understanding of functionally important genomic regions." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-01-31 05:40:55
POSITIVE SELECTION. "It is generally accepted that positive selection (selection in favor of advantageous mutations) plays an important role in the origin of new phenotypes. In fact, the evidence of selection acting on protein-coding sequences has increased enormously in the last 20 years." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-01-31 05:43:11
EVIDENCE of selection on protein-coding and non-protein coding sequences follow. View in LinkedIn
linkedin post 2018-01-31 05:44:18
EVIDENCE #1. There is "high level of similarity between proteins (in number and function), from phenotypically very different organisms." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-01-31 05:45:33
EVIDENCE #2: "the fact that a large proportion of the nonprotein-coding DNA of eukaryotic genomes is actually functional." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-01-31 05:46:57
EVIDENCE #1+#2 "has led to many researchers to ask whether phenotypic diversity is mainly determined by changes in protein-coding sequences or in the noncoding regulatory sequences." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-01-31 05:47:52
CONCLUSION. "It is now becoming clear that natural selection acts on large portions of the noncoding genome." https://lnkd.in/dPT523x View in LinkedIn
linkedin post 2018-02-01 04:50:29
SELECTION ACROSS GENOME. "In this study, we analyzed genome-wide patterns of selection acting on different classes of sequences in a worldwide sample of eight strains of the model plant-pathogenic fungus Colletotrichum graminicola. We found evidence of selective sweeps, balancing selection, and positive selection affecting both protein-coding and noncoding DNA of pathogenicity-related sequences." https://lnkd.in/dPT523x View in LinkedIn