Month: September 2022

MORTAL NORMAL CELLS. “By mid century the immortality of cancer cells was demonstrated in vitro, followed by the finding that, contrary to prevailing belief, cultured normal cells are mortal.” https://lnkd.in/esfPTAR View in LinkedIn

NORMAL LIFESPAN. “We suggested that the finite capacity of normal cells to replicate was a reflection of ageing or longevity determination at the cell level, an idea that received substantial support in subsequent years.” https://lnkd.in/esfPTAR View in LinkedIn

CANCER CELLS ARE IMMORTAL. "What allows a cancer cell to keep diving endlessly, generation upon generation? Here’s an emerging answer: The human embryo and many of our adult organs possess a tiny population of stem cells that are capable of immortal regeneration. Stem cells are the body’s reservoir of renewal. The entirety of human blood, for instance, can arise from a single, highly potent blood-forming stem cell that typically lives buried inside the bone marrow." And many cancers arise from stem cells. https://lnkd.in/eNxs3pb View in LinkedIn

MICRO-RNA (MiRNA) “also serve a crucial role in stem-cell research — they are the mechanism by which stem cells differentiate. Most cancers, we have recently learned, are marked by alterations in miRNA. Researchers even suspect that alterations in miRNA may be a cause of cancer.” http://wedcrew.yolasite.com/resources/Jelly%20fish.pdf View in LinkedIn

CALORY RESTRICTION. “Studies dating back a century have reported the healthspan and lifespan benefits of diets restricted in caloric content yet sufficient in macro- and micro-nutrients. These diets of “undernutrition without malnutrition” have been documented to have the ability to slow the progression of aging in multiple organ systems and in multiple species.” https://lnkd.in/efX_jTG View in LinkedIn

MOUSE MODEL. “Ames dwarf (Prop1df/df) mice are remarkably long-lived and exhibit many characteristics of delayed aging and extended healthspan. Caloric restriction has similar effects on healthspan and lifespan, and causes an extension of longevity in Ames dwarf mice.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072255 View in LinkedIn

LONGEVITY GENE. “The hypopituitary Ames Dwarf Mouse was the seminal example of single-gene regulation of mammalian longevity. The mice homozygous for a hypomorphic df mutation in the Prophet of Pit1, paired-like homeodomain transcription factor (PROP paired-like homeobox 1) (Prop1) gene have deficient development of the anterior portion of the pituitary gland. Consequently, they are deficient in the production of growth hormone, thyroid stimulating hormone, and prolactin.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072255 View in LinkedIn

GROWTH HORMONE MUTANTS. “Multiple other growth hormone signaling-deficient mouse mutants exhibiting longevity have since been reported.” http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072255 View in LinkedIn

FINITE CELL DIVISION."Death takes place because a worn-out tissue cannot forever renew itself, and because a capacity for increase by means of cell division is not everlasting but finite." (Weismann, 1881). http://protein.bio.msu.ru/biokhimiya/contents/v62/full/62111380.html View in LinkedIn

AUTUMN LEAVES seem best to illustrate Weismann’s worn out cell idea; after the wear and tear of a season of respiration, photosynthesis, disease and battering by the elements, leaf defects are multiple and very hard to repair: it is easier to jettison the leaf and start over again than to repair multiple cellular defects. View in LinkedIn