Month: September 2022

UNFAIR ADVANTAGE. "As a consequence, mutations in the evolved host genomes that confer resistance to parasites occur at high rates, which help the coevolved hosts outrun their parasites. Our experiments with an artificial system demonstrate how the naturally ubiquitous process of coevolution can promote complexity and favor evolvability." (In silico studies). https://lnkd.in/dUUFYJe View in LinkedIn

BIOCHEMICAL EVIDENCE. "The evidence for co-evolution discussed so far is phenomenological; an alternative approach is to look for evidence for co-evolution at the biochemical level." https://lnkd.in/d3-W8NW View in LinkedIn

MOLECULAR COEVOLUTION. "Functional mimicry of host molecules (for example, Salmonella SptP mimicking host GAP enzymes or, commonly, mimicry to evade the immune response) also raises the possibility of molecule-for-molecule co-evolution, although there is not yet evidence that hosts do, or can, respond by evading the mimics." https://lnkd.in/d3-W8NW View in LinkedIn

CANDIDATES. "The molecular biology underlying host–pathogen co-evolution is, in general, only poorly understood, but there is a huge literature on molecule-for-molecule interactions between hosts and pathogens, and these are obvious candidates for co-evolution." https://lnkd.in/d3-W8NW View in LinkedIn

MULTIVARIANT DOCKING. "One challenge is to understand how populations evolve traits that require multiple interacting changes, such as specific deformations in the reactive pocket of an enzyme or the specialized modifications of an appendage." http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf View in LinkedIn

TRANSITORY INTERMEDIATE GENOTYPES. "If each intermediate genotype leading to the new function is more fit than its immediate predecessor, then the new function can evolve readily, even if the fitness benefits do not accrue from the new function per se." http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf View in LinkedIn

INTERMEDIATE FITNESS REQUIRED. "By contrast, the evolution of a new function will be slower and more difficult, although not impossible, if any of the requisite intermediates have lower fitness than their progenitors." http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf View in LinkedIn

COMPLEX DOCKING OBJECTIVE. "We sought to understand how the adaptive landscape led to an innovation whereby bacteriophage l evolved the new ability to exploit a receptor, OmpF, on Escherichia coli cells. Previous work showed that this ability evolved repeatedly, despite requiring four mutations in one virus gene." http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf View in LinkedIn

INTERMEDIATE GENEALOGIES. "Here, we examine how this innovation evolved by studying six intermediate genotypes of l isolated during independent transitions to exploit OmpF and comparing them to their ancestor. All six intermediates showed large increases in their adsorption rates on the ancestral host." http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf View in LinkedIn

MOVING TARGET. "Improvements in adsorption were offset, in large part, by the evolution of host resistance, which occurred by reduced expression of LamB, the usual receptor for l. As a consequence of host coevolution, the adaptive landscape of the virus changed such that selection favouring four of the six virus intermediates became stronger after the host evolved resistance, thereby accelerating virus populations along the path to using the new OmpF receptor." http://rspb.royalsocietypublishing.org/content/royprsb/283/1839/20161528.full.pdf View in LinkedIn