linkedin post 2020-02-29 05:40:52

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FALSE TRAILS. “Thus the behavior of the Wnt signaling pathway depends on the previous lineage, the “where and when” questions of embryonic development. Similarly the behavior of the immune system depends on previous experience in a variable environment. All of these features stress how inadequate an explanation for function we can achieve solely by trying to identify genes (by annotating them!) and characterizing their transcriptional control circuits.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-02-29 05:43:01

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MOUNTAIN OF DATA. “With the completion of the human genome and the genomes of other species, we have a glimpse of many more genes than we ever had before to study. We are like naturalists discovering a new continent, enthralled with the diversity itself.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-02-29 05:44:59

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COMBINATORIAL AMPLIFICATION. “In response, we have argued that combinatorial use of small numbers of components can generate all the diversity that is needed. This has had its recent incarnation in the simplistic view that the rules of cis-regulatory control on DNA can directly lead to an understanding of organisms and their evolution.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-02-29 05:46:50

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KEY INTERACTIONS. “Yet this assumes that the gene products can be linked together in arbitrary combinations, something that is not assured in chemistry. It also downplays the significant regulatory features that involve interactions between gene products, their localization, binding, posttranslational modification, degradation, etc.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-03-01 06:05:42

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CONSERVED GENES. “More and more we come to realize that understanding the conserved genes and their conserved circuits will require an understanding of their special properties that allow them to function together to generate different phenotypes in different tissues of metazoan organisms.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-03-01 06:07:09

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GENERATING DIVERSITY. “These circuits may have certain robustness, but more important they have adaptability and versatility. The ease of putting conserved processes under regulatory control is an inherent design feature of the processes themselves. Among other things it loads the deck in evolutionary variation and makes it more feasible to generate useful phenotypes upon which selection can act.” https://lnkd.in/dwxby67 View in LinkedIn
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