Month: September 2022

HYDRATION FINGERPRINTS. "The processing of the genetic information within DNA is facilitated by highly discriminatory and strong protein binding. It has been shown that the interfacial water molecules can serve as "hydration fingerprints" of a given DNA sequence." https://lnkd.in/ekqUhp2 View in LinkedIn

DNA REPAIR. "The normal "hydration fingerprint" of the DNA will clearly be disrupted by DNA damage and this will facilitate repair protein attachment." https://lnkd.in/ekqUhp2 View in LinkedIn

WATER AROUND DNA. "The hydration spine is capable of carrying messages as facilitated by proton movement down the water wire, between binding sites in a similar, if complementary, manner to high electron transfer through DNA residues, and so coordinate the repair process." https://lnkd.in/ekqUhp2 View in LinkedIn

SPECIFICITY. "The major driving force for the specificity of protein binding is the entropy increase due to the decrease of bound water molecules, with the DNA sequence determining the hydration pattern in the major and minor grooves" of the DNA molecule. https://lnkd.in/ekqUhp2 View in LinkedIn

RIBOSOMES. "Highly structured water molecules with lengthy residence times, have been found to be essential for the structural dynamics and function of ribosomes...where water communicates structural rearrangements in an analogous manner to its action around many proteins." https://lnkd.in/ekqUhp2 View in LinkedIn

REACTIVE WATER. "Proteins are most stable when they are surrounded by fully hydrogen-bonded water molecules, as water molecules with spare hydrogen bonding capacity have higher entropy and are more aggressive. Such reactive water behaves in a similar way to raising the temperature and is the cause of the denaturing behavior of proteins in heating." https://lnkd.in/eSbeYHN View in LinkedIn

ORDERED WATER. "A water layer with a thickness of up to 35 nm exists at hydrophobic surfaces. This layer is characterized by a more ordered network of hydrogen bonds than liquid water." https://lnkd.in/e7guwhy View in LinkedIn

WATER AT SURFACES. "Water at a hydrophobic surface loses a hydrogen bond, therefore had increased enthalpy. Water molecules compensate for this by doing pressure-volume work, that is, the network expands to form low-density water with lower entropy. Water covers the surface with clathrate-like pentagons in partial dodecahedra, so avoiding the loss of most of the hydrogen bonds." https://lnkd.in/e7guwhy View in LinkedIn

"INTRACELLULAR WATER is a more ordered state than pure water. This water is not solely a medium but a metabolic reactant, catalyst, chaperone, messenger and controller. The water is essential for biomolecular recognition and orchestrates the cell machinery." https://lnkd.in/e4G7JTS View in LinkedIn

CELLULAR WATER. "The molecular processes in the restricted environments are largely dominated by interactions, vibrational energy transfer, orientation of water molecules, which differ drastically from those of bulk water properties." https://lnkd.in/eK4Reve View in LinkedIn