Month: September 2022

"REPLICATIVE-DEFECTIVE viral mutant strains provide a new form of viral vaccine that combines some of the advantages of each of the two classic vaccine forms. Replication-defective mutant viruses are specifically defective for viral functions that are essential for viral genome replication and assembly of progeny virus particles." https://lnkd.in/eCpd2iP View in LinkedIn

"DEFECTIVE VIRUSES, thought for decades to be essentially garbage unrelated to the transmission of normal viruses, now appear able to play an important role in the spread of disease." Few things in nature, it seems repeatedly, actually turn out to be garbage. https://lnkd.in/eAvD9w4 View in LinkedIn

DEFECTIVE VIRUS. "From a virologic standpoint it is noninfectious material of no consequence, and from an immunologic standpoint it is the by-product of a viral mechanism to stay one step ahead of the cellular and humoral responses." https://lnkd.in/egPav5U View in LinkedIn

NEW THINKING. "The idea has always been that defective viruses are either meaningless or detrimental...We have found the opposite of that — that the defective virus is actually helping the normal, functional virus." https://lnkd.in/eAvD9w4 View in LinkedIn

HUBRIS. We forever completely under-estimate the sheer scale of nature's originality. https://lnkd.in/eAvD9w4 View in LinkedIn

HUBRIS. We forever completely under-estimate the sheer scale of nature's originality. https://lnkd.in/eAvD9w4 View in LinkedIn

DENGUE VIRUS infects some 50-100 million people annually in Southeast Asia, South America and parts of the United States. In 1998, a pandemic of dengue resulted in 1.2 million cases of dengue hemorrhagic fever in 56 countries." Actual fatality 1-4%. https://lnkd.in/eGjnM8R View in LinkedIn

DEFECTIVE DENGUE VIRUS. "From 2001 to 2002, it went from being quite rare to being in all nine people we sampled that year...Everyone sampled who was getting dengue fever was getting the defective version along with the functional virus. It rose from being rare to being very common in just one year." https://lnkd.in/eGjnM8R View in LinkedIn

DEFECTIVE HELP. "The causes of epidemics are much more complicated than we thought...The combination of the defective virus with the normal virus was "more fit" than the normal dengue virus alone." https://lnkd.in/eGjnM8R View in LinkedIn

SAMPLING ARTIFACT. "The detection of DI viruses in vivo is technically difficult as they appear to be generated in only low levels, but DI/defective genomes have recently been reported from infections of a number of vertebrate species including humans." https://lnkd.in/egCZeY2 View in LinkedIn