Month: September 2022

ENDOGENOUS GENOME PROOFREADING. "Cells protect themselves from accidental genome change with proofreading and DNA damage repair systems; localized point mutations result from the action of specialized trans-lesion mutator DNA polymerases." https://lnkd.in/eNNF3BJ View in LinkedIn

MUTATOR DNA POLYMERASES. "Adaptive point mutation and amplification are induced responses to environmental stress, promoting genetic changes that can enhance survival." (E. Coli). https://lnkd.in/eJ456JB View in LinkedIn

POLYMERASE TYPES. "DNA polymerases are enzymes that synthesize DNA. These proteins have an essential role in genome duplication, but they are also critical for protecting the cell against the effects of DNA damage. There are fifteen different DNA polymerases encoded in mammalian genomes, which are specialized for replication, repair or the tolerance of DNA damage. New evidence is emerging for lesion-specific and tissue-specific functions of DNA polymerases." https://lnkd.in/e_FVkkp View in LinkedIn

NEW VIEWPOINT. "Our appreciation of the DNA transactions that replicate and maintain a stable human genome is changing rapidly due to recent discoveries indicating that eukaryotic cells contain many more DNA polymerases than previously thought.' http://www.sciencedirect.com/science/article/pii/S1535610803000278 View in LinkedIn

POLYMERASE PROOFREADING. A fabulous animation. Show your kids. https://lnkd.in/eknx3VA View in LinkedIn

"PROOFREADING is the primary guardian of DNA polymerase fidelity. New work has revealed that polymerases with intrinsic proofreading activity may cooperate with non-proofreading polymerases to ensure faithful DNA replication." https://lnkd.in/ecNyeKK View in LinkedIn

FRAGMENT FROM NATURE continues from last weekend with a consideration of global DNA or total global genetic information. A gene is the software that code for proteins that does the work of running the cell. Gene innovations are amplified in proteins due to cooperative effects. Using proteins as a proxy for biodiversity follows the same logic of using DNA as a surrogate marker. Our protein universe reflects the accumulated and amplified genetic information on this planet. View in LinkedIn

DNA AS SOFTWARE. "DNA is the software of the cell." (J Craig Venter). https://lnkd.in/eJFrT_P View in LinkedIn

"THE PROTEIN UNIVERSE, a concept first mentioned in 1992, is the collection of all proteins of every biological species that lives or has lived on earth. It is a very large, poorly defined, even mysterious entity, which also happens to be an essential underpinning of all biology." https://lnkd.in/evmEhB5 View in LinkedIn

CURATED PROTEINS. "Now, there are almost 8 million sequences in a nonredundant (NR) database of protein sequences, including the complete genomes of ≈1,800 different species. This large body of data is doubling in size every 28 months." https://lnkd.in/evmEhB5 View in LinkedIn