Month: September 2022

FATE OF GENES. "Seminal theory concerning the fates of duplicate genes predicted that the duplicate copy would be shielded from purifying selection by the ancestral copy, thus promoting pseudogenization in the absence of positive selection for a rare acquired function." https://lnkd.in/eHCDVhZ View in LinkedIn

POOR THEORETICAL FIT. "The preservation of large numbers of duplicate genes derived from ancient polyploidy events is difficult to reconcile with a model in which null alleles at duplicate loci are easily fixed by genetic drift." https://lnkd.in/eHCDVhZ View in LinkedIn

NEW TWIST. "Duplicate genes show evidence of purifying selection more consistent with buffering of the ancestral gene function than neofunctionalization reconciled Ohno's original theory with more recent observations by proposing subfunctionalization as a means of preserving duplicate genes in the presence of degenerative mutations targeting both members of a duplicate pair." https://lnkd.in/eHCDVhZ View in LinkedIn

NEW THINKING. "This hypothesis, known as the duplication-degeneration-complementation (DDC) process, posits that degenerative mutations may knock out independent subfunctions encoded by discrete regulatory elements in duplicate genes, thus requiring preservation of both copies in order to maintain the full complement of ancestral gene functions." https://lnkd.in/eHCDVhZ View in LinkedIn

Fireworks of the future? Japan to create fake shooting stars View in LinkedIn

RETENTION OF CONNECTIONS. "More recent models of duplicate gene evolution suggest that rates of duplicate gene retention vary among protein functional groups. Observations of high retention rates among more connected proteins are consistent with the gene balance hypothesis, which predicts that the fate of duplicate genes largely depends on maintaining a stoichiometric balance among members of macromolecular complexes." https://lnkd.in/eHCDVhZ View in LinkedIn

DIVERGENCE. "We find the pattern of duplicate gene retention following the Salicoid WGD in Populus broadly consistent with the predictions of the gene balance hypothesis. Approximately half of the Salicoid duplicate gene pairs showed patterns of divergence that suggest many whole genome duplicates are not subject to constraints for maintenance of redundancy." (WGD = whole genome duplication). https://lnkd.in/eHCDVhZ View in LinkedIn

RANDOM VS SELECTIVE GENE PRESERVATION. "Our findings imply the patterns of retention and functional conservation observed following duplication events are contingent upon both random and selective forces, although one or the other tends to predominate depending upon the type of duplication and the biochemical function of the gene." https://lnkd.in/eHCDVhZ View in LinkedIn

DUPLICATED HEMOGLOBIN GENES. "Gene Duplication and Evolutionary Innovations in Hemoglobin-Oxygen Transport. During vertebrate evolution, duplicated hemoglobin (Hb) genes diverged with respect to functional properties as well as the developmental timing of expression." https://lnkd.in/exfGXzx View in LinkedIn

HEMOGLOBIN GENES. "The subfamilies of genes that encode the different subunit chains of Hb are ontogenetically regulated such that functionally distinct Hb isoforms are expressed during different developmental stages. In some vertebrate taxa, functional differentiation between co-expressed Hb isoforms may also contribute to physiologically important divisions of labor." http://physiologyonline.physiology.org/content/31/3/223 View in LinkedIn